2. Neuronal Signaling Metabolic Enzyme/Protease
  3. Monoamine Oxidase Endogenous Metabolite
  4. β-Aminopropionitrile hydrochloride

β-Aminopropionitrile hydrochloride  (Synonyms: BAPN hydrochloride)

目录号: HY-Y1750A
产品使用指南

摩尔计算器

β-Aminopropionitrile (BAPN) hydrochloride 是一种特异的、不可逆赖的、具有口服活性的氨酰氧化酶 (LOX) 抑制剂。β-Aminopropionitrile hydrochloride 靶向 LOX 或 LOXL 同工酶的活性位点。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

β-Aminopropionitrile hydrochloride Chemical Structure

β-Aminopropionitrile hydrochloride Chemical Structure

CAS No. : 646-03-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

β-Aminopropionitrile hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of β-Aminopropionitrile hydrochloride:

β-Aminopropionitrile hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes[1][2].

IC50 & Target

Lysyl Oxidase

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

β-Aminopropionitrile (BAPN) normalizes the expression of GLUT4 and adiponectin, and improves glucose uptake in an in vitro model of insulin resistance[1].
β-Aminopropionitrile (500 μM; 72 h) blocks the hypoxia-induced EMT morphological and marker protein changes, and inhibits invasion and migration capacities of cervical carcinoma cells in vitro[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

β-Aminopropionitrile hydrochloride 相关抗体:

Western Blot Analysis[1]

Cell Line: 3T3-L1 adipocytes
Concentration: 200 μM with 1.15 nM and 2.87 nM TNFα
Incubation Time: 72 h
Result: TNFα reduced expression of GLUT4 and adiponectin, and increased SOCS3 protein levels in these cells. And these effects were prevented.

Cell Invasion Assay[2]

Cell Line: HeLa and SiHa cells
Concentration: 500 μM
Incubation Time: 72 h
Result: Significantly reduced hypoxia-elicited cell invasion in both cell models.

Cell Migration Assay [2]

Cell Line: HeLa and SiHa cells
Concentration: 500 μM
Incubation Time: 72 h
Result: Decreased hypoxia-induced migration from 180 and 240% to 60 and 70% in HeLa and SiHa cells, respectively.

Western Blot Analysis[2]

Cell Line: HeLa and SiHa cells
Concentration: 500 μM
Incubation Time: 72 h
Result: Effectively prevented hypoxia-induced downregulation of E-cadherin and strongly inhibited hypoxia-induced upregulation of α-SMA and vimentin.
体内研究
(In Vivo)

β-Aminopropionitrile (BAPN) (100 mg/kg/day; p.o.; 6 weeks) reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats[1].
β-Aminopropionitrile monofumarate (1 g/kg/day; p.o.; 4 weeks) induces thoracic aortic dissection in C57BL/6 mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats of 150 g, high-fat diet (HFD) model[1]
Dosage: 100 mg/kg/day
Administration: In the drinking water, 6 weeks
Result: Significantly prevented the rise in body weight in HFD rats, but not in animals that were fed a standard diet. Reduced the increase in the weight of white adipose tissue (both epididymal and lumbar) in obese animals and attenuated their enhanced adiposity. Improved fasted glucose and insulin levels and consequently reduced HOMA index in the HFD group. Improved insulin signalling in adipose tissue from obese animals.
Animal Model: C57BL/6 mice[3]
Dosage: 1 g/kg/day
Administration: In the drinking water, 4 weeks
Result: Induce thoracic aortic dissection (TAD) in all mice with 24 h of Ang II infusion. Caused 87% of C57BL/6 mice to develop TAD without Ang II.
分子量

106.55

Formula

C3H7ClN2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

β-Aminopropionitrile hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Aminopropionitrile646-03-7BAPNMonoamine OxidaseEndogenous MetaboliteMAOthoracic aortic dissectionGLUT4insulincervical carcinoma cellsHeLaSiHaobesitylysyl oxidaseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
β-Aminopropionitrile hydrochloride
目录号：
HY-Y1750A
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z