2. Apoptosis
  3. Apoptosis
  4. β-Apopicropodophyllin

β-Apopicropodophyllin 是一种天然产物，可以从 Hyptis wticillata 中分离得到。β-Apopicropodophyllin 通过诱导微管破坏、DNA 损伤、细胞周期停滞和 ER 应激来诱导细胞凋亡。β-Apopicropodophyllin 可用于癌症研究。

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β-Apopicropodophyllin Chemical Structure

β-Apopicropodophyllin Chemical Structure

CAS No. : 477-52-1

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β-Apopicropodophyllin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-Apopicropodophyllin is a nature product that could be isolated from Hyptis wticillata.β-Apopicropodophyllin induces apoptosis by inducing microtubule disruption, DNA damage, cell cycle arrest and ER stress. β-Apopicropodophyllin can be used in research of cancer[1].

体外研究
(In Vitro)

β-Apopicropodophyllin (0-100 nM; 48和72 h) 对 A549、NCI-H1299 和 NCI-460 细胞系具有抗癌活性，IC50 值分别为 16.9、13.1 和 17.1 nM [1]。
β-Apopicropodophyllin (0-20 nM; 24和48小时; A549, NCI-H1299 和 NCI-460细胞系) 破坏细胞内微管的聚合[1]。
β-Apopicropodophyllin (0-20 nM; 0-24 h; A549, NCI-H1299 和 NCI-460细胞株) 通过激活 ATM 诱导 DNA 损伤，将细胞周期阻滞在 G2/M 期，诱导内质网应激[1]。
β- apoopicropodophyllin (15 和 20 nM; 48小时; A549, NCI-H1299 和 NCI-460 细胞系) 诱导体外凋亡细胞死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

β-Apopicropodophyllin 相关抗体:

Cell Viability Assay[1]

Cell Line: A549, NCI-H1299 and NCI-460 cells
Concentration: 0-100 nM
Incubation Time: 48 and 72 hors
Result: Inhibited cell growth in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: A549, NCI-H1299 and NCI-460 cells
Concentration: 15 and 20 nM
Incubation Time: 48 h
Result: Increased the percentage of apoptotic death in A549, NCI-H1299 and NCI-H460 cell groups in a time-dependent manner.

Cell Cycle Analysis[1]

Cell Line: A549, NCI-H1299 and NCI-460 cells
Concentration: 0-20 nM
Incubation Time: 8 and 16 h
Result: Arrested cell cycle in G2/M phase.

Western Blot Analysis[1]

Cell Line: A549, NCI-H1299 and NCI-460 cells
Concentration: 0-20 nM
Incubation Time: 24 and 48 hors
Result: Decreased the level of insoluble protein containing polymeric microtubules in a time-dependent manner in non-small cell lung cancer cell lines.

Western Blot Analysis[1]

Cell Line: A549, NCI-H1299 and NCI-460 cells
Concentration: 0-20 nM
Incubation Time: 24 h
Result: Increased phosphorylated ATM and γ-H2AX levels in a dose-dependent manner.
体内研究
(In Vivo)

β-Apopicropodophyllin (1 和 5 mg/kg; 瘤内注射; 异种移植裸鼠) 以剂量依赖性方式延缓肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: nude mice with xenografts[1]
Dosage: 1 and 5 mg/kg
Administration: intra-tumorous injection
Result: Inhibited tumor growth of NSCLC xenografts in nude mice.
分子量

396.39

Formula

C22H20O7
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

β-Apopicropodophyllin 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

β-Apopicropodophyllin477-52-1Apoptosisnature productHyptis wticillatamicrotubule disruptionDNA damagecancerInhibitorinhibitorinhibit

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