2. Apoptosis
  3. Apoptosis
  4. [1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol

[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol 

目录号: HY-120654
产品使用指南 技术支持

[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol (compound 13g) 是一种三联苯衍生物，可阻断细胞周期在 G0-G1 期并诱导白血病细胞分化。[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol 显示出有效的细胞凋亡 (apoptotic) 作用。

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[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol Chemical Structure

[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol Chemical Structure

CAS No. : 890854-82-7

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规格 价格 是否有货 数量
1 mg ￥496
3 - 4 周
5 mg ￥2056
3 - 4 周
10 mg   询价  
50 mg   询价  

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[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol (compound 13g) is a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. [1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol shows a potent apoptotic effect[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HL-60 IC50
7 μM
Compound: 14
Antiproliferative activity against human HL60 cells after 48 hrs by trypan blue method
Antiproliferative activity against human HL60 cells after 48 hrs by trypan blue method
[PMID: 19764793]
K562 IC50
20 μM
Compound: 14
Antiproliferative activity against human K562 cells after 48 hrs by trypan blue method
Antiproliferative activity against human K562 cells after 48 hrs by trypan blue method
[PMID: 19764793]
K562 IC50
20 μM
Compound: 1
Antiproliferative activity against human K562 cells assessed as growth inhibition after 48 hrs by trypan blue dye exclusion method
Antiproliferative activity against human K562 cells assessed as growth inhibition after 48 hrs by trypan blue dye exclusion method
[PMID: 25221651]
K562 IC50
75 μM
Compound: 14
Induction of apoptosis in human K562 cells assessed as morphological changes after 48 hrs by annexin V assay
Induction of apoptosis in human K562 cells assessed as morphological changes after 48 hrs by annexin V assay
[PMID: 19764793]
U373-MAGI EC50
8.8 μM
Compound: 6
Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as inhibition of viral infection preincubated for 2 hrs prior to infection followed by compound wash out measured after 48 hrs by single round replication assay
Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as inhibition of viral infection preincubated for 2 hrs prior to infection followed by compound wash out measured after 48 hrs by single round replication assay
[PMID: 23010273]
分子量

278.30

Formula

C18H14O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol890854-82-7Apoptosisterphenyl derivativeG0-G1 phasedifferentiationapoptoticInhibitorinhibitorinhibit

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