2. GPCR/G Protein Neuronal Signaling Apoptosis
  3. 5-HT Receptor Apoptosis
  4. 1-(1-Naphthyl)piperazine hydrochloride

1-(1-Naphthyl)piperazine hydrochloride  (Synonyms: 1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride)

目录号: HY-112538
产品使用指南

摩尔计算器

1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) 是 Quipazine (HY-W028142) 的血清素能衍生物。1-1-Naphthylpiperazine hydrochloride 既是 5-HT1A 受体的激动剂，也是 5-HT2A 受体的拮抗剂。1-1-Naphthylpiperazine hydrochloride 可以诱导细胞凋亡 (apoptosis)。1-1-Naphthylpiperazine hydrochloride 可以预防免疫抑制和光致癌。

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1-(1-Naphthyl)piperazine hydrochloride Chemical Structure

1-(1-Naphthyl)piperazine hydrochloride Chemical Structure

CAS No. : 104113-71-5

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1-(1-Naphthyl)piperazine hydrochloride 相关抗体

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

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  • 参考文献

生物活性

1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) is a serotonergic derivative of quipazine, which is both an agonist for 5-HT1A receptor and an antagonist for 5-HT2A receptor. 1-1-Naphthylpiperazine hydrochloride induces cell apoptosis. 1-1-Naphthylpiperazine hydrochloride prevents the immunosuppression and photocarcinogenesis[1].

IC50 & Target

5-HT1A Receptor

 

5-HT2A Receptor

 

体外研究
(In Vitro)

1-1-Naphthylpiperazine hydrochloride (50-300 μM) 通过在 S 期阻滞细胞周期，诱导细胞凋亡以及 ROS 生产的方式，抑制黑色素瘤细胞 MNT-1，IC50 为 163.6 μM[1]。
1-1-Naphthylpiperazine hydrochloride (0-200 μM) 可以调节与紫外线诱导的免疫抑制有关的基因表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1-(1-Naphthyl)piperazine hydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: MNT-1
Concentration: 50-300 μM
Incubation Time: 3-24 h
Result: Inhibited cell viability

RT-PCR[1]

Cell Line: MNT-1
Concentration: 0-150 μM
Incubation Time: 24 h
Result: Downregulated levels of PAK1, upregulated levels of PTGS2 and IL12A.
体内研究
(In Vivo)

1-1-Naphthylpiperazine hydrochloride (1 μM，腹腔注射，单剂量) 通过核苷酸切除修复 (NER) 机制促进紫外线辐射诱导的 DNA 修复，从而预防 UVB 暴露的 C57BL/6 小鼠的免疫抑制并干扰光致癌作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: UVB-radiation exposed C57BL/6 mice and XPA-/- mice[2]
Dosage: 1 μM
Administration: i.p., single dose
Result: Accelerated the repair of UV-induced photoproducts with presence of NER.
分子量

248.75

Formula

C14H17ClN2
CAS 号
中文名称

1-萘酚哌嗪盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

1-(1-Naphthyl)piperazine hydrochloride 相关分类

  • 摩尔计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-(1-Naphthyl)piperazine104113-71-51-NP1-Naphthylpiperazine1-萘酚哌嗪盐酸盐5-HT ReceptorApoptosisSerotonin Receptor5-hydroxytryptamine ReceptorSK-MEL-28MNT-1C57BL/6 mouseXPA-/- mouseInhibitorinhibitorinhibit

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