2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. 1,2,3,6,7,8-Hexachlorodibenzofuran

1,2,3,6,7,8-Hexachlorodibenzofuran  (Synonyms: 1,2,3,6,7,8-HxCDF)

目录号: HY-W762015
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1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) 是一种类 polychlorinated dibenzofuran (PCDF)。1,2,3,6,7,8-Hexachlorodibenzofuran 诱导 H-4-II-E 大鼠肝癌细胞中芳烃羟化酶 (AHH) 和乙氧基间苯甲素- O-去乙基化酶 (EROD) 基因的表达 (EC50s分别= 1.47 和 1.24 nM)。1,2,3,6,7,8-Hexachlorodibenzofuran 能减轻大鼠体重，诱导胸腺萎缩，并诱导细胞色素P450 (CYP) 亚型 CYP1A1 和 4-chlorobiphenyl hydroxylase 基因的表达 (EC50s = 3.2、0.9、0.35和0.21 µmol/kg)。

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1,2,3,6,7,8-Hexachlorodibenzofuran Chemical Structure

1,2,3,6,7,8-Hexachlorodibenzofuran Chemical Structure

CAS No. : 57117-44-9

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1,2,3,6,7,8-Hexachlorodibenzofuran 相关抗体

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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生物活性

1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 1,2,3,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 1.47 and 1.24 nM, respectively). 1,2,3,6,7,8-Hexachlorodibenzofuran reduces weight, induces thymic atrophy, and induces the expression of genes encoding the cytochrome P450 (CYP) isoform CYP1A1 and 4-chlorobiphenyl hydroxylase in rats (EC50s = 3.2, 0.9, 0.35, and 0.21 µmol/kg, respectively)[1][2][3].

IC50 & Target

CYP1A1

 

分子量

374.86

Formula

C12H2Cl6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

1,2,3,6,7,8-Hexachlorodibenzofuran 相关分类

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Keywords:

1,2,3,6,7,8-Hexachlorodibenzofuran57117-44-91,2,3,6,7,8-HxCDFCytochrome P450CYPsPCDFAHHERODcytochrome P4504-chlorobiphenyl hydroxylaseInhibitorinhibitorinhibit

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