2. Apoptosis
  3. Ferroptosis
  4. 1(R)-(Trifluoromethyl)oleyl alcohol

1(R)-(Trifluoromethyl)oleyl alcohol (compound (R)-24) 是油酸 (HY-N1446) 的三氟甲基衍生物，在 Friedreich 共济失调 (FRDA) 的多种模型中具有活性。1(R)-(Trifluoromethyl)oleyl alcohol 可抑制 Erastin (HY-15763) 诱导的铁死亡，并降低敲低 frataxin (FXN) 的 NBT 人类成肌细胞中的脂质过氧化。1(R)-(Trifluoromethyl)oleyl alcohol 在 40 μM 能够使 FAC (HY-B1645) 和 BSO (HY-106376) 诱导的细胞死亡模型中细胞的存活率达到 95%。

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1(R)-(Trifluoromethyl)oleyl alcohol Chemical Structure

1(R)-(Trifluoromethyl)oleyl alcohol Chemical Structure

CAS No. : 2644636-20-2

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1(R)-(Trifluoromethyl)oleyl alcohol 相关抗体

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生物活性

1(R)-(Trifluoromethyl)oleyl alcohol (compound (R)-24) is a trifluoromethyl alcohol derivative of Oleic acid (HY-N1446) with activity in multiple models of Friedreich ataxia (FRDA). 1(R)-(Trifluoromethyl)oleyl alcohol inhibits ferroptosis induced by Erastin (HY-15763) and decreases lipid peroxidation in NBT human myoblasts with frataxin (FXN) siRNA knockdown. 1(R)-(Trifluoromethyl)oleyl alcohol at 40 μM increases survival to 95% in a model of FRDA where a significant percentage of cell death is caused by FAC (HY-B1645) and BSO (HY-106376)[1].

分子量

336.48

Formula

C19H35F3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

1(R)-(Trifluoromethyl)oleyl alcohol 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

1(R)-(Trifluoromethyl)oleyl alcohol2644636-20-2Ferroptosistrifluoromethyl alcoholFriedreich ataxiaFRDAferroptosislipid peroxidationNBT human myoblastsfrataxinFXNInhibitorinhibitorinhibit

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