2. Metabolic Enzyme/Protease
  3. 11β-HSD
  4. 11β-HSD1-IN-11

11β-HSD1-IN-11 (Compound c1a) 是一种竞争性的 11β-HSD1 抑制剂，对大鼠和人的 11β-HSD1 的 IC50 分别为 0.34 μM 和 0.13 μM。

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11β-HSD1-IN-11 Chemical Structure

11β-HSD1-IN-11 Chemical Structure

CAS No. : 859721-81-6

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规格 价格 是否有货 数量
1 mg ￥2205
1 - 2 周
5 mg   询价  
10 mg   询价  

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11β-HSD1-IN-11 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

11β-HSD1-IN-11 (Compound c1a) is a competitive 11β-HSD1 inhibitor with IC50s of 0.34 μM and 0.13 μM against rat and human 11β-HSD1, respectively[1].

IC50 & Target

IC50: 0.13 μM (Rat 11β-HSD1), 0.34 μM (Human 11β-HSD1)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
190 nM
Compound: chart 1, Wyeth
Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISA
Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISA
[PMID: 19053753]
体内研究
(In Vivo)

A single dose of the 11β-HSD1 inhibitor Merck 544 reduced the overall abundance of 11β-HSD1-IN-11 (Compound c1a) (15 mg/kg; oral gavage; once) in the rat liver[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

328.31

Formula

C15H11F3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

11β-HSD1-IN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

11β-HSD1-IN-11859721-81-611β-HSD11beta-HSD11β-hydroxysteroid dehydrogenases11 beta-hydroxysteroid dehydrogenase11β-HSD1diabetescognitive declineInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-151627
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