2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Cytochrome P450 Na+/K+ ATPase
  4. 17(S)-HETE

17S-HETE 是通过细胞色素 P-450 途径产生的花生四烯酸代谢物。17S-HETE 可以作为细胞色素 P450 1B1 的变构激活剂和 ATPase 抑制剂，可以诱导心脏肥大。

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17(S)-HETE Chemical Structure

17(S)-HETE Chemical Structure

CAS No. : 183509-25-3

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Customer Review

Other Forms of 17(S)-HETE:

17(S)-HETE 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

17S-HETE is arachidonic acid metabolite through cytochrome P-450 pathways. 17S-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy[1][2].

IC50 & Target

CYP1B1

 

体外研究
(In Vitro)

17S-HETE (5-20 μM) 通过促进 CY1B1 的活性和蛋白质水平来促进人心脏肥大的发展[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

17(S)-HETE 相关抗体:

Real Time qPCR[1]

Cell Line: AC16
Concentration: 5-20 µM
Incubation Time: 24 h
Result: Increased β/α-MHC ratio, mRNA levels of β-MHC, ANP and CYP1B1, cell surface area by 124%, 250%, 120%, 210% and 117%, respectively.

Western Blot Analysis[1]

Cell Line: AC16
Concentration: 20 µM
Incubation Time: 24 h
Result: Increased levels of CYP1B1.
体内研究
(In Vivo)

17S-HETE (1-20 μg，动脉注射) 抑制新西兰白兔的近端小管 ATP 酶活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand White rabbit[2]
Dosage: 1-20 μg
Administration: injection into artery
Result: Inhibited more than 70% ATPase activity at the concentration of 2 μM.
分子量

320.47

Formula

C20H32O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

17(S)-HETE 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

17(S)-HETE183509-25-3Cytochrome P450Na+/K+ ATPaseCYPsSodium potassium pumpcardiac hypertrophyAC16Inhibitorinhibitorinhibit

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目录号：
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