2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. 17-trifluoromethylphenyl trinor Prostaglandin F2α

17-trifluoromethylphenyl trinor Prostaglandin F2α  (Synonyms: 17-Trifluoromethylphenyl trinor PGF2α)

目录号: HY-116679
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17-trifluoromethylphenyl trinor Prostaglandin F2α (17-Trifluoromethylphenyl trinor PGF2α) 已被用于青光眼的研究。其中，未取代或间位取代的芳香族衍生物 是最有效的 FP 受体激动剂。17-trifluoromethylphenyl trinor Prostaglandin F2α 带有芳香环，让人联想到曲伏前列素 ((+)-氟前列醇异丙酯) 的三氟甲基苯氧基环。作为眼部降压剂，预计 17-trifluoromethylphenyl trinor Prostaglandin F2α 的作用与曲伏前列素的游离酸非常相似。17-trifluoromethylphenyl trinor Prostaglandin F2α 是一种有效的黄体溶解剂，其效力等于或大于氟前列醇和氯前列醇。

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17-trifluoromethylphenyl trinor Prostaglandin F2α Chemical Structure

17-trifluoromethylphenyl trinor Prostaglandin F2α Chemical Structure

CAS No. : 221246-34-0

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17-trifluoromethylphenyl trinor Prostaglandin F2α 相关抗体

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DP EP FP IP TXA2/TP TXB2

  • 生物活性

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生物活性

A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic, with a potency equal to or greater than fluprostenol and cloprostenol.

分子量

456.50

Formula

C24H31F3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

17-trifluoromethylphenyl trinor Prostaglandin F2α 相关分类

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Keywords:

17-trifluoromethylphenyl trinor Prostaglandin F2α221246-34-017-Trifluoromethylphenyl trinor PGF2αProstaglandin ReceptorInhibitorinhibitorinhibit

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