2. Neuronal Signaling
  3. Amyloid-β
  4. 2,3-Dehydrosilybin A

2,3-Dehydrosilybin A 是促进长寿和抗聚集的化合物。

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2,3-Dehydrosilybin A Chemical Structure

2,3-Dehydrosilybin A Chemical Structure

CAS No. : 25166-14-7

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规格 价格 是否有货 数量
1 mg ￥3502
3 - 4 周
5 mg   询价  
10 mg   询价  

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Other Forms of 2,3-Dehydrosilybin A:

2,3-Dehydrosilybin A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2,3-Dehydrosilybin A is a pro-longevity and anti-aggregation compound[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DU-145 IC50
11.48 μM
Compound: 2
Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 3 days by WST-1 assay
Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 3 days by WST-1 assay
[PMID: 27261177]
HUVEC IC50
12 μM
Compound: 1
Cytotoxicity in HUVEC assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity in HUVEC assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 27015547]
HUVEC IC50
12.2 μM
Compound: 1
Antimigratory activity in HUVEC assessed as inhibition of cell migration measured after 16 to 20 hrs by crystal violet staining-based microscopic analysis
Antimigratory activity in HUVEC assessed as inhibition of cell migration measured after 16 to 20 hrs by crystal violet staining-based microscopic analysis
[PMID: 27015547]
HUVEC IC50
5.4 μM
Compound: 1
Antiproliferative activity in HUVEC assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity in HUVEC assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 27015547]
LNCaP IC50
3.09 μM
Compound: 2
Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability after 3 days by WST-1 assay
Antiproliferative activity against human LNCAP cells assessed as reduction in cell viability after 3 days by WST-1 assay
[PMID: 27261177]
PC-12 EC50
30.2 μM
Compound: DHS
Neuroprotective activity against H2O2-induced injury in rat PC12 cells treated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay
Neuroprotective activity against H2O2-induced injury in rat PC12 cells treated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay
[PMID: 19673490]
PC-3 IC50
9.45 μM
Compound: 2
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 3 days by WST-1 assay
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 3 days by WST-1 assay
[PMID: 27261177]
Rat1 IC50
155 μM
Compound: DHS, enantiomeric mixture
Cytotoxicity against rat immortalized Rat1 cells after 48 hrs by MTT assay
Cytotoxicity against rat immortalized Rat1 cells after 48 hrs by MTT assay
[PMID: 21737270]
体外研究
(In Vitro)

2,3-dehydrosilybin A (DHS A)在短命线虫中具有延长寿命的潜力。
2,3-dehydrosilybin A (DHS A)促进人和线虫细胞的抵抗能力。
2,3-dehydrosilybin A在人类和线虫中可以减缓阿尔茨海默病的进展。
2,3-dehydrosilybin A在线虫中的效果依赖于FGT-1和DAF-16途径。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2,3-Dehydrosilybin A 相关抗体:
分子量

480.42

Formula

C25H20O10
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2,3-Dehydrosilybin A 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,3-Dehydrosilybin A25166-14-7Amyloid-ββ-amyloid peptideAβAbetaanti-aggregationAlzheimer's diseaseFGT-1DAF-16Inhibitorinhibitorinhibit

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