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  4. 2′,3′-Dideoxy-5-ethyluridine

2′,3′-Dideoxy-5-ethyluridine  (Synonyms: ddEtUrd)

目录号: HY-116240
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2′,3′-Dideoxy-5-ethyluridine (ddEtUrd)是一种抗逆转录病毒化合物，具有较弱的抗HIV活性。2′,3′-Dideoxy-5-ethyluridine的3'-取代衍生物未显示出显著的抗病毒效果。2′,3′-Dideoxy-5-ethyluridine在对人MT4淋巴细胞的HIV复制抑制方面的效力较低。尽管2′,3′-Dideoxy-5-ethyluridine诱导的磷酸化对抗病毒活性至关重要，但其与人类dThd激酶或dCyd激酶的亲和力之间没有密切关联。

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2′,3′-Dideoxy-5-ethyluridine Chemical Structure

2′,3′-Dideoxy-5-ethyluridine Chemical Structure

CAS No. : 108895-49-4

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2′,3′-Dideoxy-5-ethyluridine 相关抗体

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  • 生物活性

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生物活性

2′,3′-Dideoxy-5-ethyluridine (ddEtUrd) is an antiretroviral compound with weak anti-HIV activity. The 3'-substituted derivatives of 2′,3′-Dideoxy-5-ethyluridine did not show significant antiviral effects. 2′,3′-Dideoxy-5-ethyluridine was less potent in inhibiting HIV replication in human MT4 lymphocytes. Although phosphorylation induced by 2′,3′-Dideoxy-5-ethyluridine is essential for antiviral activity, there is no strong correlation between its affinity for human dThd kinase or dCyd kinase[1].

分子量

240.26

Formula

C11H16N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2′,3′-Dideoxy-5-ethyluridine 相关分类

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Keywords:

2′,3′-Dideoxy-5-ethyluridine108895-49-4ddEtUrdOthersInhibitorinhibitorinhibit

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