2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Thymidylate Synthase
  4. 2'-Deoxyuridine (Standard)

2'-Deoxyuridine (Standard)  (Synonyms: 2'-脱氧尿苷 (Standard))

目录号: HY-D0186R 纯度: ≥98%
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2'-Deoxyuridine (Standard) 是 2'-Deoxyuridine 的分析标准品。本产品用于研究及分析应用。2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD).

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2'-Deoxyuridine (Standard) Chemical Structure

2'-Deoxyuridine (Standard) Chemical Structure

CAS No. : 951-78-0

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生物活性

2'-Deoxyuridine (Standard) is the analytical standard of 2'-Deoxyuridine. This product is intended for research and analytical applications. 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD). In Vitro:The interaction between the 2-deoxyuridine and the column increases the duration of retention of 2-deoxyuridine.
Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min.
In Vivo:2'-Deoxyuridine (34.42 ng/mL, gavage, 15 min) passes the blood-brain barrier (BBB) to enter the hippocampus of mice brain.
2'-Deoxyuridine (20 mg/kg, gavage, daily for 4 weeks) improves cognition and memory loss and attenuates the damage to the hippocampus in Aβ25-35-induced mice model.
分子量

228.20

Formula

C9H12N2O5
CAS 号
中文名称

2'-脱氧尿苷 (Standard)； 2-脱氧尿苷 (Standard)
结构分类
初始来源
储存方式

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纯度 & 产品资料

2'-Deoxyuridine (Standard) 相关分类

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Keywords:

2'-Deoxyuridine (Standard)951-78-02'-脱氧尿苷 (Standard) 2-脱氧尿苷 (Standard)Endogenous MetaboliteThymidylate Synthasebrain-penetrantnervous system diseaseschromosome breakagemicroglial activationoxidative stress damageAlzheimer’s diseaseInhibitorinhibitorinhibit

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