2. Immunology/Inflammation
  3. NO Synthase
  4. 2′-Hydroxy-2,3-dimethoxychalcone

2′-Hydroxy-2,3-dimethoxychalcone 

目录号: HY-164361
产品使用指南

摩尔计算器

α-Gracinoic acid 是一种 Chalcone (HY-121054) 衍生物，具有抗炎活性。α-Gracinoic acid 抑制脂多糖 (LPS) 处理的 RAW 264.7 细胞诱导型一氧化氮合酶 (iNOS) 催化的一氧化氮生成。

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2′-Hydroxy-2,3-dimethoxychalcone Chemical Structure

2′-Hydroxy-2,3-dimethoxychalcone Chemical Structure

CAS No. : 42220-80-4

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2′-Hydroxy-2,3-dimethoxychalcone 相关抗体

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nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Gracinoic acid is a Chalcone (HY-121054) derivative with anti-inflammatory activity. α-Gracinoic acid inhibits nitric oxide production catalyzed by inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-treated RAW 264.7 cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780cisR GI50
14.38 μM
Compound: 4
Growth inhibition of cisplatin-resistant human A2780cis cells after 7 days by crystal violet staining based clonogenic assay
Growth inhibition of cisplatin-resistant human A2780cis cells after 7 days by crystal violet staining based clonogenic assay
[PMID: 24565968]
RAW264.7 IC50
3.8 μM
Compound: 15
Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay
Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay
[PMID: 19233646]
分子量

284.31

Formula

C17H16O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2′-Hydroxy-2,3-dimethoxychalcone 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2′-Hydroxy-2,3-dimethoxychalcone42220-80-4NO SynthaseNitric oxide synthasesNOSDerivativesAnti-inflammatory activityLPSNitric oxide synthaseRAW 264.7Inhibitorinhibitorinhibit

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