2. NF-κB Anti-infection Apoptosis Autophagy
  3. NF-κB Fungal Apoptosis Autophagy
  4. 2′-Hydroxychalcone

2′-Hydroxychalcone  (Synonyms: 2'-羟基查尔酮)

目录号: HY-W012349 纯度: 97.45%
COA 产品使用指南 技术支持

2'-Hydroxychalcone 是查尔酮的羟基衍生物，具有抗癌活性。2'-Hydroxychalcone 抑制 NF-κB 通路并诱导乳腺癌细胞自噬 (autophagy) 和凋亡 (apoptosis)。2′-Hydroxychalcone 对复合副球孢子菌属显示出更好的抗真菌活性。

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2′-Hydroxychalcone Chemical Structure

2′-Hydroxychalcone Chemical Structure

CAS No. : 1214-47-7

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥220
In-stock
100 mg ￥200
In-stock
500 mg ￥390
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1 g   询价  
5 g   询价  

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2′-Hydroxychalcone 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells[1]. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp[2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780cisR GI50
13.45 μM
Compound: 6
Growth inhibition of cisplatin-resistant human A2780cis cells after 7 days by crystal violet staining based clonogenic assay
Growth inhibition of cisplatin-resistant human A2780cis cells after 7 days by crystal violet staining based clonogenic assay
[PMID: 24565968]
A549 IC50
> 20 μM
Compound: 2
Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay
Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay
[PMID: 19883086]
HK-2 IC50
24.4 μM
Compound: 8
Growth inhibition of HK2 cells by sulforhodamine assay
Growth inhibition of HK2 cells by sulforhodamine assay
[PMID: 17383189]
HL-60 IC50
18 μM
Compound: 2
Cytotoxicity against human HL60 cells by MTT assay
Cytotoxicity against human HL60 cells by MTT assay
[PMID: 25091929]
HT-29 IC50
85 μM
Compound: 8
Growth inhibition of HT29 cells by sulforhodamine assay
Growth inhibition of HT29 cells by sulforhodamine assay
[PMID: 17383189]
K562 IC50
60.7 μM
Compound: 1
Cytotoxicity against Homo sapiens (human) K562 cells after 72 hr by MTT assay
Cytotoxicity against Homo sapiens (human) K562 cells after 72 hr by MTT assay
10.1007/s00044-010-9344-z
L929 CC50
79.5 μM
Compound: 1
Cytotoxicity in mouse NCTC-929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity in mouse NCTC-929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31000155]
MCF7 IC50
78 μM
Compound: 8
Growth inhibition of MCF7 cells by sulforhodamine assay
Growth inhibition of MCF7 cells by sulforhodamine assay
[PMID: 17383189]
MOLM-13 GI50
> 10 μM
Compound: 1
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 32975953]
MV4-11 GI50
> 10 μM
Compound: 1
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 32975953]
NALM-6 IC50
37.5 μM
Compound: 2
Cytotoxicity against human NALM6 cells by MTT assay
Cytotoxicity against human NALM6 cells by MTT assay
[PMID: 25091929]
PBMC IC50
11 μg/mL
Compound: 15
Immunosuppressive activity in human PBMC assessed as inhibition of PHA-induced T cell proliferation after 72 hrs by [3H]thymidine incorporation assay
Immunosuppressive activity in human PBMC assessed as inhibition of PHA-induced T cell proliferation after 72 hrs by [3H]thymidine incorporation assay
10.1007/s00044-013-0564-x
PBMC IC50
19.7 μg/mL
Compound: 15
Immunosuppressive activity in human PBMC assessed as inhibition of PHA/PMA-induced IL-2 production after 18 hrs by ELISA
Immunosuppressive activity in human PBMC assessed as inhibition of PHA/PMA-induced IL-2 production after 18 hrs by ELISA
10.1007/s00044-013-0564-x
SK-N-MC IC50
61.2 μM
Compound: 1
Cytotoxicity against Homo sapiens (human) SK-N-MC cells after 72 hr by MTT assay
Cytotoxicity against Homo sapiens (human) SK-N-MC cells after 72 hr by MTT assay
10.1007/s00044-010-9344-z
THP-1 GI50
> 10 μM
Compound: 1
Antiproliferative activity against human THP-1 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human THP-1 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 32975953]
TK-10 IC50
79 μM
Compound: 8
Growth inhibition of TK10 cells by sulforhodamine assay
Growth inhibition of TK10 cells by sulforhodamine assay
[PMID: 17383189]
WM-115 IC50
40.8 μM
Compound: 2
Cytotoxicity against human WM115 cells by MTT assay
Cytotoxicity against human WM115 cells by MTT assay
[PMID: 25091929]
体外研究
(In Vitro)

2'-Hydroxychalcone（10-90 μM；12-72 h）以剂量依赖性方式抑制细胞活力，对于两种乳腺癌细胞系 MCF-7 和 CMT-1211 的 IC50 值分别为 37.74 μM 和 34.26 μM [1]。
2'-Hydroxychalcone（10-30 μM；24 小时）促进乳腺癌细胞自噬囊泡积聚[1]。
2'-Hydroxychalcone（30 μM；24 小时）可诱导乳腺癌细胞发生自噬依赖性细胞凋亡，并增加 caspase-3 和 PARP 的裂解[1]。
2′-Hydroxychalcone（10-30 μM；24 小时）显着降低 p-IκB 和 p-NF-κBp65 的表达，并提高 p-ERK 和 p-JNK 的水平[1]。
2'-Hydroxychalcone（30 μM；12-24 小时）可增加乳腺癌细胞的细胞内 ROS 水平并触发内质网应激[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2′-Hydroxychalcone 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF-7 and CMT-1211 cells
Concentration: 10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, and 90 μM
Incubation Time: 12 h, 24 h, 36 h, 48 h, 60 h, and 72 h
Result: Suppressed cell viability in a dose-dependent manner.

Cell Autophagy Assay[1]

Cell Line: MCF-7 and CMT-1211 cells
Concentration: 10 μM, 20 μM, 30 μM
Incubation Time: 24 h
Result: Induced autophagy and promoted autophagy flux in breast cancer cells.

Apoptosis Analysis[1]

Cell Line: MCF-7 and CMT-1211 cells
Concentration: 30 μM
Incubation Time: 24 h
Result: Induced autophagy-dependent apoptosis of breast cancer cells.

Western Blot Analysis[1]

Cell Line: MCF-7 and CMT-1211 cells
Concentration: 10 μM, 20 μM, 30 μM
Incubation Time: 24 h
Result: Regulated MAPK/NF-κB signaling pathways and inhibited migration/invasion of breast cancer cells.
体内研究
(In Vivo)

2'-Hydroxychalcone（20-60 mg/kg；腹腔注射；每 2 天；3 周）可在体内表现出抗肿瘤作用，而不会对重要器官造成明显毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old Balb/C female mice injected with CMT-1211 cells[1]
Dosage: 20 mg/kg, 40 mg/kg, 60 mg/kg
Administration: Intraperitoneal injection; every 2 days; 3 weeks
Result: Suppressed tumor growth and metastasis in vivo.
分子量

224.25

Formula

C15H12O2
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

2'-羟基查尔酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 200 mg/mL (891.86 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.4593 mL 22.2965 mL 44.5931 mL
5 mM 0.8919 mL 4.4593 mL 8.9186 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 97.45%

COA (287 KB) HNMR (124 KB) GC (174 KB)

产品使用指南 (1538 KB)
参考文献

2′-Hydroxychalcone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4593 mL 22.2965 mL 44.5931 mL 111.4827 mL
5 mM 0.8919 mL 4.4593 mL 8.9186 mL 22.2965 mL
10 mM 0.4459 mL 2.2297 mL 4.4593 mL 11.1483 mL
15 mM 0.2973 mL 1.4864 mL 2.9729 mL 7.4322 mL
20 mM 0.2230 mL 1.1148 mL 2.2297 mL 5.5741 mL
25 mM 0.1784 mL 0.8919 mL 1.7837 mL 4.4593 mL
30 mM 0.1486 mL 0.7432 mL 1.4864 mL 3.7161 mL
40 mM 0.1115 mL 0.5574 mL 1.1148 mL 2.7871 mL
50 mM 0.0892 mL 0.4459 mL 0.8919 mL 2.2297 mL
60 mM 0.0743 mL 0.3716 mL 0.7432 mL 1.8580 mL
80 mM 0.0557 mL 0.2787 mL 0.5574 mL 1.3935 mL
100 mM 0.0446 mL 0.2230 mL 0.4459 mL 1.1148 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2′-Hydroxychalcone1214-47-72'-羟基查尔酮NF-κBFungalApoptosisAutophagyNuclear factor-κBNuclear factor-kappaBanticancer activitiesautophagyapoptosisantifungal activityInhibitorinhibitorinhibit

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