2. Vitamin D Related/Nuclear Receptor
  3. VD/VDR
  4. 2MD

2MD 是一种口服活性维生素 D 类似物。2MD 刺激骨膜骨形成，减少小梁骨吸收。因此，2MD 可以恢复小梁和皮质骨质量和强度。在非人灵长类动物中，2MD 还能调节眼压 (IOP) 相关基因并降低非人类灵长类动物眼压。

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2MD Chemical Structure

2MD Chemical Structure

CAS No. : 213250-70-5

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2MD 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2MD is an orally active vitamin D analog. 2MD stimulates periosteal bone formation and decreases trabecular bone resorption. Thus 2MD restores trabecular and cortical bone mass and strength. 2MD also regulates intraocular pressure (IOP)-relative genes and reduces IOP in non-human primates[1][2].

体内研究
(In Vivo)

2MD (5 μg/eye; 滴注; 单次剂量) 处理 7-8 小时后，可使食蟹猴同侧眼眼压逐渐降低 20%，对侧眼眼压逐渐降低至 15% 或更低[1]。
2MD (0.5-10 ng/kg, 0,1 mL/day; 口服给药; 每天 1 次, 共 16 周) 不仅可以恢复骨小梁和皮质骨质量，还可以通过刺激骨膜表面骨形成和减少骨小梁表面骨吸收，增加大鼠的骨质量和强度[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ovariectomized (OVX) rats model (Sprague-Dawley female rats; 4-month-old)[2]
Dosage: 0.5, 1, 2.5, 5, and 10 ng/kg, 0,1 mL/day
Administration: Oral gavage; once daily for 16 weeks
Result: Significantly increased serum calcium at 2.5, 5, or 10 ng/kg/day.
Dose-dependent reduction in osteoclast number and trabecular osteoclast surface, and dose-dependent increased in periosteal bone formation.
Clinical Trial
分子量

416.64

Formula

C27H44O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2MD 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2MD213250-70-5VD/VDRVitamin DVitamin D receptorInhibitorinhibitorinhibit

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