2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. 3-(3-Phenoxybenzyl)amino-β-carboline

3-(3-Phenoxybenzyl)amino-β-carboline 

目录号: HY-150511
产品使用指南

摩尔计算器

3-(3-Phenoxybenzyl)amino-β-carboline 是一种有效的微管蛋白 (tubulin) 抑制剂。3-(3-Phenoxybenzyl)amino-β-carboline 促进 αβ- 微管蛋白异二聚体的选择性降解。3-(3-Phenoxybenzyl)amino-β-carboline 诱导 G2/M 期细胞周期阻滞和凋亡 (apoptosis)。3-(3-Phenoxybenzyl)amino-β-carboline 具有抗癌活性。

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3-(3-Phenoxybenzyl)amino-β-carboline Chemical Structure

3-(3-Phenoxybenzyl)amino-β-carboline Chemical Structure

CAS No. : 1327080-54-5

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3-(3-Phenoxybenzyl)amino-β-carboline 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780S IC50
45 nM
Compound: 2
Antiproliferative activity against human A2780S cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Antiproliferative activity against human A2780S cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 35084853]
HeLa IC50
51 nM
Compound: 2
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 35084853]
HeLa S3 IC50
0.074 μM
Compound: 10e
Cytotoxicity against human HeLaS3 cells after 24 to 72 hrs by MTT assay
Cytotoxicity against human HeLaS3 cells after 24 to 72 hrs by MTT assay
[PMID: 22520257]
HeLa S3 IC50
0.074 μM
Compound: 2h
Cytotoxicity against human HeLaS3 cells after 24 to 72 hrs by MTT assay
Cytotoxicity against human HeLaS3 cells after 24 to 72 hrs by MTT assay
[PMID: 21752645]
MCF7 IC50
49 nM
Compound: 2
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 35084853]
NCI-H460 IC50
62 nM
Compound: 2
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 35084853]
Raji IC50
31 nM
Compound: 2
Antiproliferative activity against human Raji cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Antiproliferative activity against human Raji cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 35084853]
Sarcoma-180 IC50
0.03 μM
Compound: 10e
Cytotoxicity against mouse Sarcoma 180 cells after 24 to 72 hrs by MTT assay
Cytotoxicity against mouse Sarcoma 180 cells after 24 to 72 hrs by MTT assay
[PMID: 22520257]
体外研究
(In Vitro)

3-(3-Phenoxybenzyl)amino-β-carboline specifically denatures tubulin, making it prone to aggregation that predisposes it to ubiquitinylation and then degradation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3-(3-Phenoxybenzyl)amino-β-carboline 相关抗体:
分子量

365.43

Formula

C24H19N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3-(3-Phenoxybenzyl)amino-β-carboline 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-(3-Phenoxybenzyl)amino-β-carboline1327080-54-5Microtubule/TubulinApoptosisHeLa cellsHct116H460SU-DHL-6 cellsanticancerInhibitorinhibitorinhibit

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