2. Membrane Transporter/Ion Channel
  3. BCRP
  4. 3,7,2',4'-Tetramethoxy-5-hydroxyflavone

3,7,2',4'-Tetramethoxy-5-hydroxyflavone 

目录号: HY-149469
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BCRP/ABCG2-IN-1 是乳腺癌耐药蛋白 (BCRP/ABCG2) 的抑制剂，IC50 为 5.98 μM，可用于乳腺癌的多药耐药研究。

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3,7,2',4'-Tetramethoxy-5-hydroxyflavone Chemical Structure

3,7,2',4'-Tetramethoxy-5-hydroxyflavone Chemical Structure

CAS No. : 19056-75-8

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3,7,2',4'-Tetramethoxy-5-hydroxyflavone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BCRP/ABCG2-IN-1 is the inhibitor of breast cancer resistance protein (BCRP/ABCG2), with IC50 of 5.98 μM, that can be used in multidrug resistance of breast cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDCK-II IC50
3.27 μM
Compound: 13
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of Hoechst 33342 preincubated for 30 mins before Hoechst 33342 addition measured after 120 mins by fluorescence assay
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of Hoechst 33342 preincubated for 30 mins before Hoechst 33342 addition measured after 120 mins by fluorescence assay
[PMID: 23851114]
MDCK-II IC50
3.89 μM
Compound: 13
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of pheophorbide-A preincubated for 30 mins before pheophorbide-A addition measured after 120 mins by flow cytometry
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of pheophorbide-A preincubated for 30 mins before pheophorbide-A addition measured after 120 mins by flow cytometry
[PMID: 23851114]
分子量

358.34

Formula

C19H18O7
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3,7,2',4'-Tetramethoxy-5-hydroxyflavone 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3,7,2',4'-Tetramethoxy-5-hydroxyflavone19056-75-8BCRPBreast cancer resistance proteinABCG2BCRP/ABCG2 InhibitorBreast CancerInhibitorinhibitorinhibit

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