3-Aminopropylphosphinic acid  (Synonyms: 3-APPA; CGP 27492; CGA 147823)

3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of GABA. 3-Aminopropylphosphinic acid is a potent, selective GABA_B receptor agonist^[1].

GABAB^[1]

3-Aminopropylphosphinic acid (10 μM) causes a concentration-dependent inhibition of the cholinergic twitch contraction in the electrically stimulated ileum (IC₅₀=1.84-0.23 μM)^[2]
3-Aminopropylphosphinic acid acts as an anti-aging substance for skin^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3-Aminopropylphosphinic acid (5 mg/kg; i.v.) blocks the inhibitory effects of GABA against vagal broncho-spasm in guinea pigs^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

123.09

C₃H₁₀NO₂P

103680-47-3

3-氨基丙烷-1-磷酸

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Luzzi S, Franchi-Micheli S, Ciuffi M, Pajani A, Zilletti L. GABA-related activities of amino phosphonic acids on guinea-pig ileum longitudinal muscle. J Auton Pharmacol. 1986 Sep;6(3):163-9.  [Content Brief]

  [2]. Hills JM, Dingsdale RA, Parsons ME, Dolle RE, Howson W. 3-Aminopropylphosphinic acid--a potent, selective GABAB receptor agonist in the guinea-pig ileum and rat anococcygeus muscle. Br J Pharmacol. 1989 Aug;97(4):1292-6.  [Content Brief]

  [3]. Chapman RW, Danko G, Rizzo C, Egan RW, Mauser PJ, Kreutner W. Prejunctional GABA-B inhibition of cholinergic, neurally-mediated airway contractions in guinea-pigs. Pulm Pharmacol. 1991;4(4):218-24.  [Content Brief]

  [4]. Cho Youn-Ki, et al. 3-Aminopropyl dihydrogen phosphate (3-APPA; 3-aminopropane phosphoric acid); a novel anti-aging substance. Journal of Investigative Dermatology, vol. 4, no. 106, 2015, p. 895.