2. 天然产物
  3. 动物 甾体类
  4. 3-Epicinobufagin

3-Epicinobufagin (compound IX) 可作为 Bufalin (HY-N0877) 的代谢内标，通过检测血清和尿液中的含量反馈对应代谢情况。

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3-Epicinobufagin Chemical Structure

3-Epicinobufagin Chemical Structure

CAS No. : 36121-84-3

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3-Epicinobufagin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3-Epicinobufagin (compound IX) can be used as an internal standard for the metabolism of Bufalin (HY-N0877), by detecting its content in serum and urine to provide feedback on the corresponding metabolic status[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
2.3 μM
Compound: 12b
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32526552]
A549 IC50
6.5 μM
Compound: 8
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
[PMID: 24050254]
BEAS-2B IC50
22.3 μM
Compound: 12b
Cytotoxicity against human BEAS-2B assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human BEAS-2B assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32526552]
Bel-7402 IC50
0.1 μM
Compound: 1
Cytotoxicity against human Bel7402 cells by MTT assay
Cytotoxicity against human Bel7402 cells by MTT assay
[PMID: 18558746]
Bel-7402 IC50
4.9 x 10-2 μM
Compound: CB
Cytotoxicity against human Bel7402 cells assessed as againsthibition of cell growth after 72 hrs
Cytotoxicity against human Bel7402 cells assessed as againsthibition of cell growth after 72 hrs
[PMID: 21205911]
Calu-3 IC50
2.3 μM
Compound: 12b
Antiproliferative activity against human Calu-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human Calu-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32526552]
CCRF S-180 IC50
> 50 μM
Compound: 2
Cytotoxicity against mouse S180 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against mouse S180 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23799775]
CNE IC50
0.31 μM
Compound: 2
Cytotoxicity against human CNE1 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human CNE1 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23799775]
CNE2Z IC50
0.39 μM
Compound: 2
Cytotoxicity against human CNE2Z cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human CNE2Z cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23799775]
H22 IC50
> 50 μM
Compound: 2
Cytotoxicity against mouse H22 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against mouse H22 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23799775]
HepG2 IC50
1.706 μM
Compound: 2
Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23799775]
HepG2 IC50
2.355 μM
Compound: 2
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23799775]
HepG2 IC50
5.5 μM
Compound: 8
Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
[PMID: 24050254]
HL-60 IC50
< 0.01 μg/mL
Compound: 12
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 11575946]
KB IC50
0.21 μg/mL
Compound: 12
Cytotoxicity against human KB cells after 72 hrs by MTT assay
Cytotoxicity against human KB cells after 72 hrs by MTT assay
[PMID: 11575946]
MH60 IC50
> 25 μg/mL
Compound: 12
Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay
Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay
[PMID: 11575946]
MH60 IC50
> 56.3 μM
Compound: 9
Growth inhibition of IL-6-independent mouse MH60 cells after 72 hrs by MTT assay
Growth inhibition of IL-6-independent mouse MH60 cells after 72 hrs by MTT assay
[PMID: 15620253]
MH60 IC50
> 56.3 μM
Compound: 9
Growth inhibition of IL6-dependent mouse MH60 cells after 72 hrs by MTT assay in presence of human recombinant IL6
Growth inhibition of IL6-dependent mouse MH60 cells after 72 hrs by MTT assay in presence of human recombinant IL6
[PMID: 15620253]
NCI-H1299 IC50
2.3 μM
Compound: 12b
Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32526552]
NCI-H460 IC50
2.3 μM
Compound: 12b
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32526552]
SK-MES-1 IC50
2.3 μM
Compound: 12b
Antiproliferative activity against human SK-MES-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human SK-MES-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32526552]
分子量

442.54

Formula

C26H34O6
CAS 号
结构分类
初始来源

Chinese toad venom preparation Ch'an Su were
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3-Epicinobufagin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Epicinobufagin36121-84-3OthersInhibitorinhibitorinhibit

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目录号：
HY-N13079
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