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  3. Drug Derivative
  4. 3-Oxobetulin acetate

3-Oxobetulin acetate  (Synonyms: 28-O-Acetyl-3-Oxobetulin; 3-oxo-28-O-Acetylbetulin)

目录号: HY-139090
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3-Oxobetulin acetate (28-O-Acetyl-3-Oxobetulin; 3-oxo-28-O-Acetylbetulin) 是胆固醇生物合成抑制剂桦木醇 (HY-N0083) 的衍生物。3-Oxobetulin acetate 可抑制 P388 鼠淋巴细胞白血病细胞 (EC50=0.12 μg/mL) 以及人类 MCF-7 乳腺癌、SF-268 CNS 癌细胞、H460 肺癌和 KM20L2 结肠癌细胞 (GI50s=8、10.6、5.2 和 12.7 μg/mL) 的生长，但不能抑制 BxPC-3 胰腺癌细胞或 DU145 前列腺癌细胞 (两者的 GI50s=>10 μg/mL)。3-Oxobetulin acetate 可抑制 X4 嗜性重组 HIV (NL4.3-Ren) 在 MT-2 淋巴母细胞中的复制 (IC50=13.4 μM)。3-Oxobetulin acetate 还可有效对抗杜氏利斯特菌无鞭毛体。

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3-Oxobetulin acetate Chemical Structure

3-Oxobetulin acetate Chemical Structure

CAS No. : 136587-07-0

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3-Oxobetulin acetate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3-Oxobetulin acetate (28-O-Acetyl-3-Oxobetulin; 3-oxo-28-O-Acetylbetulin) is a derivative of betulin (HY-N0083), a cholesterol biosynthesis inhibitor. 3-Oxobetulin acetate inhibits the growth of P388 murine lymphocytic leukemia cells (EC50=0.12 μg/mL) and human MCF-7 breast cancer, SF-268 CNS cancer, H460 lung cancer, and KM20L2 colon cancer cells (GI50s=8, 10.6, 5.2, and 12.7 μg/mL), but not BxPC-3 pancreatic cancer cells or DU145 prostate cancer cells (GI50s=>10 μg/mL for both). 3-Oxobetulin acetate inhibits the replication of X4-tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblastoid cells (IC50=13.4 μM). 3-Oxobetulin acetate is also effective against Listeria donovani amastigotes.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BXPC-3 GI50
> 10 μg/mL
Compound: 6
Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay
Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay
[PMID: 24694263]
DU-145 GI50
> 10 μg/mL
Compound: 6
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
[PMID: 24694263]
KM-20L2 GI50
12.7 μg/mL
Compound: 6
Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay
Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay
[PMID: 24694263]
MCF7 GI50
8 μg/mL
Compound: 6
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
[PMID: 24694263]
MT2 IC50
13.4 μM
Compound: 39
Antiviral activity against HIV1 NL4.3-Ren infected in human MT2 cells assessed as inhibition of viral growth measured 48 hrs post infection by luminometry
Antiviral activity against HIV1 NL4.3-Ren infected in human MT2 cells assessed as inhibition of viral growth measured 48 hrs post infection by luminometry
[PMID: 25927586]
MT2 CC50
20 μM
Compound: 39
Cytotoxicity against mock-infected human MT2 cells assessed as reduction in cell viability incubated for 48 hrs by cell-titer Glo assay
Cytotoxicity against mock-infected human MT2 cells assessed as reduction in cell viability incubated for 48 hrs by cell-titer Glo assay
[PMID: 25927586]
NCI-H460 GI50
5.2 μg/mL
Compound: 6
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
[PMID: 24694263]
P388 ED50
0.12 μg/mL
Compound: 6
Cytotoxicity against mouse P388 cells after 48 hrs
Cytotoxicity against mouse P388 cells after 48 hrs
[PMID: 24694263]
SF-268 GI50
10.6 μg/mL
Compound: 6
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
[PMID: 24694263]
分子量

482.74

Formula

C32H50O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3-Oxobetulin acetate 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Oxobetulin136587-07-028-O-Acetyl-3-Oxobetulin 3-oxo-28-O-AcetylbetulinDrug DerivativeDrug derivativeInhibitorinhibitorinhibit

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