2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 3’-β-C-Ethynyladenosine

3’-β-C-Ethynyladenosine 是一种腺嘌呤核苷类似物。腺苷类似物大多可作为平滑肌血管扩张剂，也被证明能够抑制癌症进展。它的热门产品有 Adenosine phosphate，Acadesine (HY-13417)，Clofarabine (HY-A0005)，Fludarabine phosphate (HY-B0028) 和 Vidarabine (HY-B0277)。3’-β-C-Ethynyladenosine 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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3’-β-C-Ethynyladenosine Chemical Structure

3’-β-C-Ethynyladenosine Chemical Structure

CAS No. : 180300-54-3

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3’-β-C-Ethynyladenosine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3’-β-C-Ethynyladenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1]. 3’-β-C-Ethynyladenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM IC50
0.61 μM
Compound: 5; Eado
Antiproliferative activity against human CEM cells after 72 hrs by Coulter counter method
Antiproliferative activity against human CEM cells after 72 hrs by Coulter counter method
[PMID: 30098481]
CCRF-CEM IC50
0.61 μM
Compound: 1
Cytostatic activity against human CEM cells after 72 hrs by Coulter counter method
Cytostatic activity against human CEM cells after 72 hrs by Coulter counter method
[PMID: 26965865]
HeLa IC50
0.29 μM
Compound: 5; Eado
Antiproliferative activity against human HeLa cells after 72 hrs by Coulter counter method
Antiproliferative activity against human HeLa cells after 72 hrs by Coulter counter method
[PMID: 30098481]
HeLa IC50
0.29 μM
Compound: 1
Cytostatic activity against human HeLa cells after 72 hrs by Coulter counter method
Cytostatic activity against human HeLa cells after 72 hrs by Coulter counter method
[PMID: 26965865]
L1210 IC50
0.73 μM
Compound: 5; Eado
Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counter method
Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counter method
[PMID: 30098481]
L1210 IC50
0.73 μM
Compound: 1
Cytostatic activity against mouse L1210 cells after 48 hrs by Coulter counter method
Cytostatic activity against mouse L1210 cells after 48 hrs by Coulter counter method
[PMID: 26965865]
分子量

291.26

Formula

C12H13N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

3’-β-C-Ethynyladenosine 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3’-β-C-Ethynyladenosine180300-54-3Nucleoside Antimetabolite/Analogmuscle vasodilatorInhibitorinhibitorinhibit

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