2. Academic Validation
  3. Potential and promising anticancer drugs from adenosine and its analogs

Potential and promising anticancer drugs from adenosine and its analogs

  • Drug Discov Today. 2021 Jun;26(6):1490-1500. doi: 10.1016/j.drudis.2021.02.020.
Shuli Man 1,  Yingying Lu 1,  Lijuan Yin 1,  Xinkuan Cheng 1,  Long Ma 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Lab of Metabolic Control Fermentation Technology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China.
  • 2 State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Lab of Metabolic Control Fermentation Technology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China. Electronic address: malong@tust.edu.cn.
PMID: 33639248 DOI: 10.1016/j.drudis.2021.02.020
Abstract

In recent years, many studies have shown that adenosine has efficacy for treating Cancer. More importantly, some adenosine analogs have been successfully marketed to fulfill Anticancer purposes. In this review, we summarize the Anticancer effects of adenosine and its analogs in clinical trials and preclinical studies, with focus on their Anticancer mechanisms. In addition, we link the Anticancer activities of adenosine analogs with their structures through structure-activity relationship (SAR) analysis, and highlight additional promising Anticancer drug candidates. We hope that this review will be of help in understanding the importance of adenosine and its analogs with Anticancer activities and directing future research and development of such compounds.

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