3’-beta-C-Methyladenosine

目录号: HY-152366: FAQs
Data Sheet 产品使用指南

摩尔计算器

3′-β-C-Methyladenosine 是一种腺嘌呤核苷类似物。腺苷类似物大多可作为平滑肌血管扩张剂，也被证明能够抑制癌症进展。这一系列的热门产品有 Adenosine phosphate，Acadesine (HY-13417)，Clofarabine (HY-A0005)，Fludarabine phosphate (HY-B0028) 和 Vidarabine (HY-B0277)。

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3’-beta-C-Methyladenosine Chemical Structure

CAS No. : 15397-13-4

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生物活性
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参考文献

生物活性

3′-β-C-Methyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
Caco-2	GI₅₀	23.2 μM Compound: 3'-Me-Ado	Antitumor activity against human CaCo2 cells after 48 hrs by MTS assay Antitumor activity against human CaCo2 cells after 48 hrs by MTS assay	[PMID: 18588281]
Caco-2	GI₅₀	24.3 μM Compound: 3'-Me-Ado	Antiproliferative activity against human Caco2 cells after 72 hrs by MTS assay Antiproliferative activity against human Caco2 cells after 72 hrs by MTS assay	[PMID: 21349610]
Caco-2	IC₅₀	24.3 μM Compound: 5, 3'-Me-Ado	Growth inhibition of human Caco2 cells after 48 hrs by MTT assay Growth inhibition of human Caco2 cells after 48 hrs by MTT assay	[PMID: 25304896]
HeLa	GI₅₀	23.3 μM Compound: 3'-Me-Ado	Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay	[PMID: 21349610]
HeLa	IC₅₀	23.3 μM Compound: 5, 3'-Me-Ado	Growth inhibition of human HeLa cells after 48 hrs by MTT assay Growth inhibition of human HeLa cells after 48 hrs by MTT assay	[PMID: 25304896]
HL-60	IC₅₀	15 μM Compound: 5, 3'-Me-Ado	Cytotoxicity against human HL60 cells after 24 to 48 hrs by trypan blue dye exclusion method Cytotoxicity against human HL60 cells after 24 to 48 hrs by trypan blue dye exclusion method	[PMID: 25304896]
HL-60	IC₅₀	15.6 μM Compound: 5, 3'-Me-Ado	Growth inhibition of human HL60 cells after 48 hrs by MTT assay Growth inhibition of human HL60 cells after 48 hrs by MTT assay	[PMID: 25304896]
HT-29	GI₅₀	26.1 μM Compound: 3'-Me-Ado	Antitumor activity against human HT29 cells after 48 hrs by MTS assay Antitumor activity against human HT29 cells after 48 hrs by MTS assay	[PMID: 18588281]
HT-29	GI₅₀	26.1 μM Compound: 3'-Me-Ado	Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay	[PMID: 21349610]
HT-29	IC₅₀	26.1 μM Compound: 5, 3'-Me-Ado	Growth inhibition of human HT-29 cells after 48 hrs by MTT assay Growth inhibition of human HT-29 cells after 48 hrs by MTT assay	[PMID: 25304896]
HuT78	IC₅₀	17.3 μM Compound: 5, 3'-Me-Ado	Growth inhibition of human HUT78 cells after 48 hrs by MTT assay Growth inhibition of human HUT78 cells after 48 hrs by MTT assay	[PMID: 25304896]
K562	GI₅₀	9.4 μM Compound: 3'-Me-Ado	Antitumor activity against human K562 cells after 48 hrs by MTS assay Antitumor activity against human K562 cells after 48 hrs by MTS assay	[PMID: 18588281]
K562	GI₅₀	9.4 μM Compound: 3'-Me-Ado	Antiproliferative activity against human K562 cells after 72 hrs by MTS assay Antiproliferative activity against human K562 cells after 72 hrs by MTS assay	[PMID: 21349610]
K562	IC₅₀	9.4 μM Compound: 5, 3'-Me-Ado	Growth inhibition of human K562 cells after 48 hrs by MTT assay Growth inhibition of human K562 cells after 48 hrs by MTT assay	[PMID: 25304896]
MCF7	GI₅₀	22.4 μM Compound: 3'-Me-Ado	Antitumor activity against human MCF7 cells after 48 hrs by MTS assay Antitumor activity against human MCF7 cells after 48 hrs by MTS assay	[PMID: 18588281]
MCF7	GI₅₀	22.4 μM Compound: 3'-Me-Ado	Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay	[PMID: 21349610]
MCF7	IC₅₀	22.4 μM Compound: 5, 3'-Me-Ado	Growth inhibition of human MCF7 cells after 48 hrs by MTT assay Growth inhibition of human MCF7 cells after 48 hrs by MTT assay	[PMID: 25304896]

分子量

281.27

Formula

C₁₁H₁₅N₅O₄

CAS 号

15397-13-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. [Content Brief]

3’-beta-C-Methyladenosine 相关分类

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稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3’-beta-C-Methyladenosine15397-13-4Nucleoside Antimetabolite/Analogmuscle vasodilatorInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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上海工商

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3’-beta-C-Methyladenosine

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