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  4. 4-Chloropyridine

4-Chloropyridine  (Synonyms: 4-氯基吡啶)

目录号: HY-W093017
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摩尔计算器

4-Chloropyridine 是一种烟酰胺 N-甲基转移酶 (NNMT) 抑制剂。4-Chloropyridine 可作为 NNMT 的底物，在其催化反应中通过甲基化吡啶环的氮原子，增强 C4 位置的亲电子性，从而通过芳香亲核取代反应与 NNMT 中的非催化半胱氨酸 (C159) 发生作用，最终导致 NNMT 的自杀性活性抑制。4-Chloropyridine 有望用于 NNMT 活性靶向探针 (activity-based probes) 开发研究。

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4-Chloropyridine Chemical Structure

4-Chloropyridine Chemical Structure

CAS No. : 626-61-9

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4-Chloropyridine 的其他形式现货产品:

Other Forms of 4-Chloropyridine:

4-Chloropyridine 相关抗体

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  • 生物活性

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生物活性

4-Chloropyridine is an inhibitor of nicotinamide N-methyltransferase (NNMT). It can act as a substrate for NNMT and, during its catalytic reaction, enhances the electrophilicity of the C4 position by methylating the nitrogen atom of the pyridine ring. This promotes an aromatic nucleophilic substitution reaction with the non-catalytic cysteine (C159) in NNMT, ultimately leading to the suicide inhibition of NNMT's activity. 4-Chloropyridine holds potential for the development of NNMT activity-based probes [1].

分子量

113.54

Formula

C5H4ClN
CAS 号
中文名称

4-氯基吡啶
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4-Chloropyridine 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

4-Chloropyridine626-61-94-氯基吡啶OthersInhibitorinhibitorinhibit

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