2. NF-κB Metabolic Enzyme/Protease
  3. Keap1-Nrf2 Endogenous Metabolite
  4. 4-Hydroxyphenylacetic acid (Standard)

4-Hydroxyphenylacetic acid (Standard)  (Synonyms: 4-羟基苯乙酸 (Standard))

目录号: HY-N1902R 纯度: ≥98%
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4-Hydroxyphenylacetic acid (Standard) 是 4-Hydroxyphenylacetic acid 的分析标准品。本产品用于研究及分析应用。4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2.

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4-Hydroxyphenylacetic acid (Standard) Chemical Structure

4-Hydroxyphenylacetic acid (Standard) Chemical Structure

CAS No. : 156-38-7

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生物活性

4-Hydroxyphenylacetic acid (Standard) is the analytical standard of 4-Hydroxyphenylacetic acid. This product is intended for research and analytical applications. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2. IC50 & Target:Nrf2 In Vivo: 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1.

分子量

152.15

Formula

C8H8O3
CAS 号
中文名称

4-羟基苯乙酸 (Standard)
结构分类
初始来源
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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4-Hydroxyphenylacetic acid (Standard) 相关分类

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Keywords:

4-Hydroxyphenylacetic acid (Standard)156-38-74-羟基苯乙酸 (Standard)Keap1-Nrf2Endogenous MetaboliteInhibitorinhibitorinhibit

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