2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. 4-Oxo Docosahexaenoic Acid

4-Oxo Docosahexaenoic Acid  (Synonyms: 4-oxo DHA)

目录号: HY-134997
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4-Oxo Docosahexaenoic Acid (4-oxo DHA) 是 Docosahexaenoic acid (HY-B2167) 的推定代谢物，具有抗增殖和 PPARγ 激动剂活性。它在 50-100 μM 浓度下抑制几种三阴性乳腺癌细胞系 (MCF-10F、trMCF、bsMCF、MDA-MB-231 和 BT549) 的生长，但它增加了 MCF-7 细胞的增殖。4-氧代 DHA 与 PPARγ 共价结合，并在荧光素酶报告基因检测和树突状细胞中激活基因转录，EC50 值约为 8-16 μM。

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4-Oxo Docosahexaenoic Acid Chemical Structure

4-Oxo Docosahexaenoic Acid Chemical Structure

CAS No. : 845673-74-7

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4-Oxo Docosahexaenoic Acid 相关抗体

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  • 生物活性

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生物活性

4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of Docosahexaenoic acid (HY-B2167) with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 μM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 μM.

分子量

342.47

Formula

C22H30O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4-Oxo Docosahexaenoic Acid 相关分类

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Keywords:

4-Oxo Docosahexaenoic Acid845673-74-74-oxo DHAPPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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