2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. 4-trans-Hydroxy-glibenclamide

4-trans-Hydroxy-glibenclamide  (Synonyms: 4-trans-hydroxycyclohexyl Glyburide; 4-trans-hydroxy Glibenclamide)

目录号: HY-117160
产品使用指南 技术支持

rac-trans-4-hydroxy Glyburide 是 SUR1/Kir6.2 磺酰脲类抑制剂格列苯脲 (HY-15206) 的活性代谢物。它由格列苯脲经细胞色素 P450 (CYP) 同工酶 CYP2C8 和 CYP2C9 作用而形成。rac-trans-4-hydroxy Glyburide 可抑制格列苯脲与大鼠脑突触体在 SUR1/Kir6.2 高亲和力位点和低亲和力位点的结合，IC50 值分别为 0.95 和 100 nM。

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4-trans-Hydroxy-glibenclamide Chemical Structure

4-trans-Hydroxy-glibenclamide Chemical Structure

CAS No. : 23155-00-2

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Other Forms of 4-trans-Hydroxy-glibenclamide:

4-trans-Hydroxy-glibenclamide 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide (HY-15206). It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC50 values of 0.95 and 100 nM, respectively.

分子量

510.00

Formula

C23H28ClN3O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4-trans-Hydroxy-glibenclamide 相关分类

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Keywords:

4-trans-Hydroxy-glibenclamide23155-00-24-trans-hydroxycyclohexyl Glyburide 4-trans-hydroxy GlibenclamidePotassium ChannelKcsAInhibitorinhibitorinhibit

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