5-Azacytidine-¹⁵N₄  (Synonyms: 5-氮杂胞苷-¹⁵N₄; Azacitidine-¹⁵N₄; 5-AzaC-¹⁵N₄; Ladakamycin-¹⁵N₄)

5-Azacytidine-¹⁵N₄ is ¹³C and ¹⁵N labeled 5-Azacytidine. 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy^[1][2][3][4].

248.18

C₈H₁₂¹⁵N₄O₅

2139283-40-0

320-67-2

阿扎胞苷-¹⁵N₄；阿托胞苷-¹⁵N₄；5-氮包苷-¹⁵N₄；5-氮杂胞苷-¹⁵N₄；5-氮杂胞嘧啶核苷-¹⁵N₄；氮胞苷-¹⁵N₄；氮杂胞苷-¹⁵N₄

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Li LH,et al. Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia. Cancer Res. 1970 Nov;30(11):2760-9.  [Content Brief]

  [3]. Christman JK. 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002 Aug 12;21(35):5483-95.  [Content Brief]

  [4]. Creusot F, et al. Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidineand 5-aza-2'-deoxycytidine. J Biol Chem. 1982 Feb 25;257(4):2041-8.  [Content Brief]

  [5]. Marycz K, et al. 5-Azacytidine and Resveratrol Enhance Chondrogenic Differentiation of Metabolic Syndrome-Derived Mesenchymal Stem Cells by Modulating Autophagy.Oxid Med Cell Longev. 2019 May 12;2019:1523140.  [Content Brief]