5-Carboxamidotryptamine  (Synonyms: 5-CT)

5-Carboxamidotryptamine (5-CT) is a 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT_5A, 5-HT₇ receptor agonist^[1][2][3][4]. 5-Carboxamidotryptamine has a K_i value of 4.6 nM for cloned human 5-HT_5A receptor. 5-Carboxamidotryptamine causes a dose-dependent reduction in rectal temperature of mice^[3][4].

5-Carboxamidotryptamine (0.03-3 mg/kg i.p. and 0.125-5 μg i.c.v.) causes a dose-dependent reduction in rectal temperature of mice^[3].
5-Carboxamidotryptamine (0.1-1 mg/kg; i.p.) reduces rectal temperature in wild type mice but not 5-HT₇ receptor knockout mice^[3].
5-Carboxamidotryptamine (0.0 1-1 μg/kg; i.v.) causes consistent, dose-related decreases in diastolic blood pressure and carotid arterial vascular resistance and increases in heart rate of cats. In contrast, 5-HT (1-100 μg/kg; i.v.) causes tachycardia but variable and complex effects on diastolic blood pressure and carotid arterial vascular resistance^[5].
5-Carboxamidotryptamine does not cause bronchoconstriction in cats. In contrast, 5-HT causes dose-related bronchoconstriction^[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

203.24

C₁₁H₁₃N₃O

74885-09-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Saxena PR,et al. Characterization of 5-hydroxytryptamine receptors in the cranial vasculature. Cephalalgia. 1989;9 Suppl 9:15-22.  [Content Brief]

  [2]. Saxena PR, et al. From serotonin receptor classification to the antimigraine drug sumatriptan. Cephalalgia. 1992 Aug;12(4):187-96.  [Content Brief]

  [3]. Guscott MR, Egan E, Cook GP, Stanton JA, Beer MS, Rosahl TW, Hartmann S, Kulagowski J, et al. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003 Jun;44(8):1031-7.  [Content Brief]

  [4]. Hurley PT, et al. Functional coupling of a recombinant human 5-HT5A receptor to G-proteins in HEK-293 cells. Br J Pharmacol. 1998 Jul;124(6):1238-44.  [Content Brief]

  [5]. Connor HE, et al. 5-Carboxamidotryptamine is a selective agonist at 5-hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized cats. Br J Pharmacol. 1986 Feb;87(2):417-26.  [Content Brief]