2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. 5-epi-Arvestonate A

5-epi-Arvestonate A 是一种从绢毛菊 (Seriphidium transiliense) 中分离得到的倍半萜类化合物。5-epi-Arvestonate A 通过激活小眼相关转录因子 (MITF) 和酪氨酸酶家族基因的转录，促进黑色素生成。5-epi-Arvestonate A 通过 JAK/STAT 信号通路抑制永生化人角化细胞 (HaCaT) 中 IFN-γ 趋化因子的表达。

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5-epi-Arvestonate A Chemical Structure

5-epi-Arvestonate A Chemical Structure

CAS No. : 2767066-84-0

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5-epi-Arvestonate A 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5-epi-Arvestonate A is a sesquiterpenoid isolated from the whole plants of Seriphidium transiliense. 5-epi-Arvestonate A promotes melanogenic production by activating the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes. 5-epi-Arvestonate A inhibits the expression of IFN-γ-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells[1].

体外研究
(In Vitro)

5-epi-Arvestonate A (50 μM; 48 h) activates the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes in murine melanoma (B16) cells[1].
5-epi-Arvestonate A (50 μM; 48 h) increases both the mRNA and protein level of TRP-1, TRP-2, TYR, and MITF in murine melanoma (B16) cells[1].
5-epi-Arvestonate A (10 μM, 50 μM; 24 h) disrupts the IFN-γ-chemokine and CXCL10/9 production through the JAK/STAT signal pathway in IFN-γ-activated HaCaT cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5-epi-Arvestonate A 相关抗体:

Western Blot Analysis[1]

Cell Line: Murine melanoma (B16) cells; IFN-γ-activated HaCaT cells
Concentration: 1, 10, 50 μM
Incubation Time: 24 hours and 48 hours
Result: Increased the protein level of TRP-1, TRP-2, TYR, and MITF at 50 μM concentration in murine melanoma (B16) cells.
Decreased the protein level of IFN-γ, CXCL9/10 in IFN-γ-activated HaCaT cells for 24 hr.

Cell Viability Assay[1]

Cell Line: Murine melanoma (B16) cells
Concentration: 1, 10, 50 μM
Incubation Time: 48 hours
Result: Increased the viability of B16, increased the levels of both relative melanin content and relative tyrosinase activity.
分子量

298.37

Formula

C16H26O5
CAS 号
结构分类
初始来源

Seriphidium transiliense
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

5-epi-Arvestonate A 相关分类

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Keywords:

5-epi-Arvestonate A2767066-84-0TyrosinaseSeriphidium transiliensesesquiterpenoidmurine melanoma cellsmicrophthalmia-associated transcription factortyrosinase familyJAK/STAT signaling pathwayimmortalized human keratinocyte cellsHaCaTInhibitorinhibitorinhibit

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