1. Neuronal Signaling
  2. α-synuclein
  3. 5-S-Cysteinyldopamine

5-S-Cysteinyldopamine  (Synonyms: Cysdopamine; 5-S-CyS-DA)

目录号: HY-N15255
产品使用指南 技术支持

5-S-Cysteinyldopamine 是一种多巴胺的硫醚代谢物,可通过诱导广泛的氧化应激和蛋白质聚集来诱导神经性病变,表现为蛋白质羰基化和谷胱甘肽耗竭,并上调 α-突触核蛋白 (α-Syn) 和 ERp57 蛋白的表达。5-S-Cysteinyldopamine 可用于神经退行性疾病,如帕金森病的研究。

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5-S-Cysteinyldopamine Chemical Structure

5-S-Cysteinyldopamine Chemical Structure

CAS No. : 99558-89-1

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  • 生物活性

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生物活性

5-S-Cysteinyldopamine is a sulfur ether metabolite of dopamine that can induce neurodegeneration by inducing widespread oxidative stress and protein aggregation, characterized by protein carbonylation and glutathione depletion, and upregulating the expression of α-Syn and ERp57 proteins. 5-S-Cysteinyldopamine can be used in the study of neurodegenerative diseases, such as Parkinson's disease[1][2].

IC50 & Target

α-synuclein

 

分子量

272.32

Formula

C11H16N2O4S

CAS 号
结构分类
初始来源

human brain

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
5-S-Cysteinyldopamine
目录号:
HY-N15255
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