2. Epigenetics TGF-beta/Smad
  3. PKC
  4. 7-Oxostaurosporine

7-Oxostaurosporine 是一种有效的蛋白激酶 C (PKC) 抑制剂，可通过诱导细胞凋亡(apoptosis) 和抑制核因子 (NF)-κB/p-p65 通路有效抑制肿瘤生长。

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7-Oxostaurosporine Chemical Structure

7-Oxostaurosporine Chemical Structure

CAS No. : 125035-83-8

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规格 价格 是否有货 数量
1 mg ￥6847
3 - 4 周
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7-Oxostaurosporine 相关抗体

Top Publications Citing Use of Products

查看 PKC 亚型特异性产品:

查看所有亚型
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.78 μM
Compound: 15
Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
ASPC1 IC50
1.2 μM
Compound: 15
Cytotoxicity in human ASPC1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human ASPC1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
BXPC-3 IC50
0.43 μM
Compound: 15
Cytotoxicity in human BXPC-3 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human BXPC-3 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
MGC-803 IC50
1.52 μM
Compound: 15
Cytotoxicity in human MGC-803 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human MGC-803 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
NCI-H1299 IC50
2.03 μM
Compound: 15
Cytotoxicity in human NCI-H1299 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human NCI-H1299 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
NCI-H1975 IC50
2.01 μM
Compound: 15
Cytotoxicity in human NCI-H1975 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human NCI-H1975 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
PC-9 IC50
1.88 μM
Compound: 15
Cytotoxicity in human PC-9 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human PC-9 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
RKO IC50
1.47 μM
Compound: 15
Cytotoxicity in human RKO cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human RKO cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
体外研究
(In Vitro)

7-Oxostaurosporine (50 nM, 24 h)可以导致 CHO 细胞中质膜鞘磷脂增加，但不会改变神经酰胺含量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

7-Oxostaurosporine 相关抗体:
体内研究
(In Vivo)

7-Oxostaurosporin（6 mg/kg，每天一次，静脉注射）显着降低肿瘤生长，肿瘤生长抑制（TGI）为 56.1%，对体重无明显影响[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

480.51

Formula

C28H24N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

7-Oxostaurosporine 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Oxostaurosporine125035-83-8PKCProtein kinase CapoptosisNF-κBp65tumorInhibitorinhibitorinhibit

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