2. Stem Cell/Wnt TGF-beta/Smad
  3. PKA
  4. 8-Chloro-cAMP

8-Chloro-cAMP 是一种 cAMP 类似物，可诱导生长停滞，并调节 cAMP 依赖性 PKA 活性。8-Chloro-cAMP 具有抗癌活性。

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8-Chloro-cAMP Chemical Structure

8-Chloro-cAMP Chemical Structure

CAS No. : 41941-56-4

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1 mg ￥3960
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Other Forms of 8-Chloro-cAMP:

8-Chloro-cAMP 相关抗体

Top Publications Citing Use of Products

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PKA PKAR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity[1].

体外研究
(In Vitro)

8-Chloro-cAMP markedly inhibits vascular smooth muscle cell (VSMC) proliferation in vitro, reduces protein kinase A (PKA) RIα subunit expression, and induces PKA RIIβ subunit expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

8-Chloro-cAMP 相关抗体:
体内研究
(In Vivo)

In rat bearing balloon injury, 8-Chloro-cAMP (12 mg/kg) reduces, in a dose-dependent manner, neointimal area and neointima/media ratio after balloon injury. 8-Chloro-cAMP shows a reduction of proliferative activity of VSMCs in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

363.65

Formula

C10H11ClN5O6P
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (271 KB)

产品使用指南 (1538 KB)
参考文献

8-Chloro-cAMP 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-Chloro-cAMP41941-56-4PKAProtein kinase AcAMP analogueanticancer activityInhibitorinhibitorinhibit

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