1. Apoptosis Anti-infection
  2. Thymidylate Synthase Bacterial
  3. 8-Deazahomofolic acid

8-Deazahomofolic acid 是胸腺酸合酶 (TS) 和其它叶酸相关酶的抑制剂。8-Deazahomofolic acid 对叶酸依赖性 S. faecium 菌、L. casei 菌和 MTX (HY-14519) 耐药菌株具有抑制活性。8-Deazahomofolic acid 对 L1210 白血病细胞具有生长抑制作用,IC50 值为 87.5 μM。8-Deazahomofolic acid 可用于细菌感染和肿瘤的研究。

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8-Deazahomofolic acid Chemical Structure

8-Deazahomofolic acid Chemical Structure

CAS No. : 111113-73-6

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  • 生物活性

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生物活性

8-Deazahomofolic acid is an inhibitor of thymidylate synthase (TS) and other folate-related enzymes. 8-Deazahomofolic acid shows inhibitory activity against folate-dependent S. faecium, L. casei, and MTX (HY-14519) resistant strains. 8-Deazahomofolic acid also inhibits the growth of L1210 leukemia cells, with an IC50 value of 87.5 μM. 8-Deazahomofolic acid can be used in research on bacterial infections and tumors[1].

分子量

454.44

Formula

C21H22N6O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
8-Deazahomofolic acid
目录号:
HY-124093
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