2. Stem Cell/Wnt TGF-beta/Smad
  3. PKA
  4. 8-pCPT-2'-O-Me-cAMP-AM

8-pCPT-2'-O-Me-cAMP-AM 

目录号: HY-107544 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

8-pCPT-2'-O-Me-cAMP-AM 是一类循环的 AMP 类似物，能够选择性激活 Epac-Rap 信号通路。8-pCPT-2'-O-Me-cAMP-AM 通过激活 Epack 可保护缺血损伤下的肾功能。8-pCPT-2'-O-Me-cAMP-AM 也通过与 PKA 通路相互作用刺激胰岛素分泌。

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8-pCPT-2'-O-Me-cAMP-AM Chemical Structure

8-pCPT-2'-O-Me-cAMP-AM Chemical Structure

CAS No. : 1152197-23-3

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规格 价格 是否有货 数量
100 μg ￥8000
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Customer Review

8-pCPT-2'-O-Me-cAMP-AM 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

8-pCPT-2'-O-Me-cAMP-AM is a cyclic AMP analogue, selectively activates Epac-Rap signaling pathway. 8-pCPT-2'-O-Me-cAMP-AM protects renal function by activating Epac from ischemia injury. 8-pCPT-2'-O-Me-cAMP-AM also stimulates insulin secretion by interaction with PKA pathway[1][2].

体外研究
(In Vitro)

8-pCPT-2'-O-Me-cAMP-AM (2.5 μM; 30 min) activates Epac and prevents adherens junction disassembly during hypoxia (60 min)[1].
8-pCPT-2'-O-Me-cAMP-AM can cross the plasma membrane and is able to alter diverse cellular functions that include Rap1 GTPase activity, PKB, and ERK1/2 protein kinase activity, phospholipase C activity, Ca2+ signaling, ion channel activity, exocytosis, cell adhesion, and gene expression[2].
8-pCPT-2'-O-Me-cAMP-AM stimulates insulin secretion with dose-dependent and glucose metabolism-dependent (0.1 or 1.11 mM) actions[2].
8-pCPT-2'-O-Me-cAMP-AM (20 μM) activates the cAMP reporter Epac1-camps, while 8-pCPT-2'-O-Me-cAMP doesn’t in INS-1 cells[2].
8-pCPT-2'-O-Me-cAMP-AM (0.3-3.0 μM; 0-300 sec) activates Epac1-camps in a dose- and time-dependent manner in high throughput assay[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

8-pCPT-2'-O-Me-cAMP-AM 相关抗体:
体内研究
(In Vivo)

8-pCPT-2'-O-Me-cAMP-AM (intrarenal injection; ) activates renal Rap1 and likely is caused by activation of Epac in the tubular epithelium[1].
8-pCPT-2'-O-Me-cAMP-AM preserves renal function by Epac activation and reduces tubular epithelial-cell stress during ischemia[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: IR injuried mouse model[1]
Dosage: 1.45 mM
Administration: Intrarenal injection; mice were sacrificed at 24, 48, or 72 hours after ischemia
Result: Protected renal injury during ischemia.
分子量

557.90

Formula

C20H21ClN5O8PS
CAS 号
性状

油状物

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 55.79 mg/mL (100.00 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7924 mL 8.9622 mL 17.9244 mL
5 mM 0.3585 mL 1.7924 mL 3.5849 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (294 KB)

产品使用指南 (1538 KB)
参考文献

8-pCPT-2'-O-Me-cAMP-AM 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7924 mL 8.9622 mL 17.9244 mL 44.8109 mL
5 mM 0.3585 mL 1.7924 mL 3.5849 mL 8.9622 mL
10 mM 0.1792 mL 0.8962 mL 1.7924 mL 4.4811 mL
15 mM 0.1195 mL 0.5975 mL 1.1950 mL 2.9874 mL
20 mM 0.0896 mL 0.4481 mL 0.8962 mL 2.2405 mL
25 mM 0.0717 mL 0.3585 mL 0.7170 mL 1.7924 mL
30 mM 0.0597 mL 0.2987 mL 0.5975 mL 1.4937 mL
40 mM 0.0448 mL 0.2241 mL 0.4481 mL 1.1203 mL
50 mM 0.0358 mL 0.1792 mL 0.3585 mL 0.8962 mL
60 mM 0.0299 mL 0.1494 mL 0.2987 mL 0.7468 mL
80 mM 0.0224 mL 0.1120 mL 0.2241 mL 0.5601 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-pCPT-2'-O-Me-cAMP-AM1152197-23-3PKAProtein kinase Ainsulin secretioncyclic AMP analoguerenal functionRap1 GTPase activityPKBERK1/2 protein kinasephospholipase C activityCa2+ signalingion channel activityexocytosiscell adhesionInhibitorinhibitorinhibit

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