2. NF-κB
  3. NF-κB
  4. 9-Hydroxycanthin-6-one

9-Hydroxycanthin-6-one 是一种生物碱化合物，具有 NF-κB 抑制作用，IC50 为 3.8 μM。

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9-Hydroxycanthin-6-one Chemical Structure

9-Hydroxycanthin-6-one Chemical Structure

CAS No. : 138544-91-9

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9-Hydroxycanthin-6-one 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

9-Hydroxycanthin-6-one is an alkaloid compound. 9,10-Dimethoxycanthin-6-one exhibits NF-κB inhibitory effects with an IC50 of 3.8 μM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 ED50
10 μg/mL
Compound: 9-hydroxycanthin-6-one
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
[PMID: 14575431]
Calu-3 CC50
> 100 μM
Compound: Table 1, R10C2
Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
[PMID: 36399766]
DLD-1 IC50
> 40 μM
Compound: 1
Cytotoxicity against Wnt-dependent human DLD1 cells assessed as cell viability after 24 hrs by fluorescence assay
Cytotoxicity against Wnt-dependent human DLD1 cells assessed as cell viability after 24 hrs by fluorescence assay
[PMID: 25905468]
HCT-116 IC50
30 μM
Compound: 1
Cytotoxicity against Wnt-dependent human HCT116 cells assessed as cell viability after 24 hrs by fluorescence assay
Cytotoxicity against Wnt-dependent human HCT116 cells assessed as cell viability after 24 hrs by fluorescence assay
[PMID: 25905468]
HCT-8 CC50
60.88 μM
Compound: Table 1, R10C2
Cytotoxicity against human HCT-8 cells assessed as redcution in cell viability incubated for 96 hrs by PrestoBlue reagent based assay
Cytotoxicity against human HCT-8 cells assessed as redcution in cell viability incubated for 96 hrs by PrestoBlue reagent based assay
[PMID: 36399766]
HEK293 IC50
36.7 μM
Compound: 1
Cytotoxicity against HEK293 cells assessed as cell viability after 24 hrs by fluorescence assay
Cytotoxicity against HEK293 cells assessed as cell viability after 24 hrs by fluorescence assay
[PMID: 25905468]
HEK293 IC50
6.8 μM
Compound: 1
Activation of GSK-3beta in HEK293 cells assessed as suppression of TCF/beta-catenin transcriptional activity after 24 hrs by SuperTOPFlash reporter gene assay
Activation of GSK-3beta in HEK293 cells assessed as suppression of TCF/beta-catenin transcriptional activity after 24 hrs by SuperTOPFlash reporter gene assay
[PMID: 25905468]
HEK-293T IC50
> 40 μM
Compound: 1
Cytotoxicity against HEK293T cells assessed as cell viability after 24 hrs by fluorescence assay
Cytotoxicity against HEK293T cells assessed as cell viability after 24 hrs by fluorescence assay
[PMID: 25905468]
HepG2 CC50
> 100 μM
Compound: Table 1, R10C2
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
[PMID: 36399766]
MCF7 ED50
19.6 μg/mL
Compound: 9-hydroxycanthin-6-one
Cytotoxicity against human MCF7 cells by SRB assay
Cytotoxicity against human MCF7 cells by SRB assay
[PMID: 14575431]
MRC5 CC50
> 100 μM
Compound: Table 1, R10C2
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
[PMID: 36399766]
RKO IC50
> 40 μM
Compound: 1
Cytotoxicity against Wnt-independent human RKO cells assessed as cell viability after 24 hrs by fluorescence assay
Cytotoxicity against Wnt-independent human RKO cells assessed as cell viability after 24 hrs by fluorescence assay
[PMID: 25905468]
SW480 IC50
17.4 μM
Compound: 1
Cytotoxicity against Wnt-independent human SW480 cells assessed as cell viability after 24 hrs by fluorescence assay
Cytotoxicity against Wnt-independent human SW480 cells assessed as cell viability after 24 hrs by fluorescence assay
[PMID: 25905468]
Vero CC50
> 100 μM
Compound: Table 1, R10C2
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
[PMID: 36399766]
分子量

236.23

Formula

C14H8N2O2
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

9-Hydroxycanthin-6-one 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9-Hydroxycanthin-6-one138544-91-9NF-κBNuclear factor-κBNuclear factor-kappaBalkaloidInhibitorinhibitorinhibit

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