2. GPCR/G Protein
  3. Free Fatty Acid Receptor
  4. AMG 837

AMG 837钠盐是GPR40激动剂，EC50为13 nM，具有较好的药代动力学表现。

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AMG 837 Chemical Structure

AMG 837 Chemical Structure

CAS No. : 865231-46-5

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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AMG 837 的其他形式现货产品:

Other Forms of AMG 837:

AMG 837 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMG 837 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A9 EC50
41 nM
Compound: 2, AMG 837
Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay
Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay
[PMID: 24900872]
CHO EC50
0.013 μM
Compound: AMG 837
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis
[PMID: 26620255]
CHO EC50
0.06 μM
Compound: 1, AMG-837
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
[PMID: 24900539]
CHO EC50
0.06 μM
Compound: 1, AMG 837
Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay
Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay
[PMID: 24900707]
CHO EC50
0.08 μM
Compound: AMG 837
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human serum albumin
[PMID: 26620255]
CHO EC50
104 nM
Compound: 2, AMG 837
Agonist activity at human GPR40 expressed in CHO cells by aequorin assay
Agonist activity at human GPR40 expressed in CHO cells by aequorin assay
[PMID: 24900872]
CHO EC50
8.8 μM
Compound: AMG 837
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum
Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human serum
[PMID: 26620255]
HEK293 EC50
2.2 nM
Compound: AMG-837
Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay
Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay
[PMID: 27994752]
分子量

438.44

Formula

C26H21F3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AMG 837 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG 837865231-46-5AMG837AMG-837Free Fatty Acid ReceptorFFARInhibitorinhibitorinhibit

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目录号：
HY-13967
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