AR-A 2  (Synonyms: AR-A 000002)

AR-A 2 is a selective 5-HT_1B receptor antagonist, with high affinity to guinea pig cortex 5HT_1B/1D and recombinant guinea pig 5-HT_1B receptors (K_i=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT_1D receptor (K_i, 5 nM), and shows an EC₅₀ of 4.5 nM for the guinea pig 5-HT_1B receptor; AR-A 2 can be used in the research of depression and anxiety.

AR-A 2 (AR-A000002) is a selective 5-HT_1B receptor antagonist, with high affinity to guinea pig cortex 5HT_1B/1D and recombinant guinea pig 5-HT_1B receptors (K_i=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT_1D receptors (K_i, 5 nM), and shows an EC₅₀ of 4.5 nM for the guinea pig 5-HT_1B receptor. AR-A 2 also binds to the rat cortical 5HT_1B/1D receptor (K_i, 20 nM), rat cortex 5-HT_2A receptor (K_i, 339 nM), rat hippocampus 5-HT_1A receptor (K_i, 3070 nM). In addition, AR-A 2 also exhibits affinity for dopamine D2 (K_i, 330 nM) and α1-adrenoceptors (K_i, 490 nM)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

448.60

C₂₇H₃₆N₄O₂

220051-79-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ahlgren C, et al. In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist. Eur J Pharmacol. 2004 Sep 19;499(1-2):67-75.  [Content Brief]