2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Alniditan

Alniditan  (Synonyms: Alnitidan)

目录号: HY-101698
产品使用指南

摩尔计算器

Alniditan (Alnitidan) 是一种有效的 5-HT1B 和 5-HT1D 受体激动剂，在 HEK 293 细胞中，对人 5-HT1B 和 人 5-HT1D 受体的 IC50 分别为 1.7 nM 和 1.3 nM。Alniditan 具有预防偏头痛的作用。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Alniditan dihydrochloride 通常具有更好的水溶性和稳定性。

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Alniditan Chemical Structure

Alniditan Chemical Structure

CAS No. : 152317-89-0

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Alniditan 的其他形式现货产品:

Other Forms of Alniditan:

Alniditan 相关抗体

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Alniditan (Alnitidan) is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK 293 cells, respectively. Alniditan has migraine-preventive effects[1][2].

IC50 & Target[2]

human 5-HT1B Receptor

1.7 nM (IC50, in HEK 293 cell)

human 5-HT1D Receptor

1.3 nM (IC50, in HEK 293 cell)

5-HT1B Receptor

0.9 nM (Kd)

5-HT1D Receptor

1.2 nM (Kd)

体外研究
(In Vitro)

In vitro, Alniditan exhibits little vasoconstrictive effects on the rat basilar artery, although at a very high concentration 1 mM, Alniditan causes intensive constriction, most likely through a mechanism independent from 5-HT receptor activation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Alniditan 相关抗体:
体内研究
(In Vivo)

The intraperitoneal administration of Alniditan ED50=9 μg/kg dose dependly reduces [125I]-BSA extravasation in the rat meninges when done 30 min before stimulation. Alniditan dose dependently attenuateds the neurogenic inflammation in vivo model of neurogenic inflammation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

302.41

Formula

C17H26N4O
CAS 号
中文名称

阿尼地坦
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[2]

After a stabilisation period of about 1 h, the animals are divided into three groups. In the first group (n=4), values of heart rate, mean arterial blood pressure, carotid blood flow and its distribution, as well as arterial and jugular venous blood gases are measured at baseline, and after four consecutive injections of physiological saline (0.5 mL, every 20 min). The second and third groups of animals (n=6 each) are pre-treated with saline (i.v.) or GR127935 (0.5 mg/kg, i.v.), respectively, given over a period of 5 min at a rate of 1 mL/min. After a waiting period of 15 min, baseline values of heart rate, mean arterial blood pressure, carotid blood flow and its distribution, as well as arterial and jugular venous blood gases are measured. Subsequently, these groups of animals receive sequential i.v. doses of alniditan (3, 10, 30 and 100 μg/kg) every 20 min. Fifteen minutes after each dose of alniditan, all haemodynamic variables are assessed again.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Alniditan 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alniditan152317-89-0Alnitidan阿尼地坦5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT1B5-HT1DmigrainepreventiveInhibitorinhibitorinhibit

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