2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Alosetron

Alosetron  (Synonyms: 阿洛司琼; GR 68755; GR 68755X)

目录号: HY-70050A
产品使用指南

摩尔计算器

Alosetron (GR 68755) 是一种高效、高选择性的 5-HT3 受体 (5-HT3 receptor) 拮抗剂。Alosetron 用于肠易激综合征 (IBS) 的研究。Alosetron 阻断 5HT3 介导的豚鼠肌间和粘膜下神经元的快速去极化，IC50 在 ~55 nM。Alosetron 减轻清醒或麻醉犬直肠扩张的内脏伤害性效应。具有抗炎活性。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Alosetron Hydrochloride 通常具有更好的水溶性和稳定性。

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Alosetron Chemical Structure

Alosetron Chemical Structure

CAS No. : 122852-42-0

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Alosetron 的其他形式现货产品:

Alosetron 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Alosetron (GR 68755) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects[1][2].

IC50 & Target

5-HT3 Receptor

 

体内研究
(In Vivo)

Dexamethasone and Alosetron-treated (1 mg/kg; ip; daily for 6 days) rats exhibits a significant decrease in the diarrhea index, in comparison with TNBS-control group, especially after the initial 2 days of treatment following the induction of colitis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

294.35

Formula

C17H18N4O
CAS 号
中文名称

阿洛司琼；洛曲尼斯；罗肠兴
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Alosetron 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alosetron122852-42-0GR 68755 GR 68755X阿洛司琼洛曲尼斯罗肠兴GR68755GR-687555-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorselectivedepolarizationvisceralnociceptivecolitisInhibitorinhibitorinhibit

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