2. GPCR/G Protein
  3. Amylin Receptor
  4. Amylin, amide, human

Amylin, amide, human  (Synonyms: DAP amide, human)

目录号: HY-P1070 纯度: 97.41%
COA 产品使用指南

摩尔计算器

Amylin, amide, human 是一种 37 个氨基酸的多肽，是一种与胰岛素共分泌的胰腺激素，在代谢和葡萄糖稳态中发挥独特作用。Amylin, amide, human 抑制胰高血糖素分泌，延迟胃排空，并作为饱腹感剂。

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Custom Peptide Synthesis

Amylin, amide, human Chemical Structure

Amylin, amide, human Chemical Structure

CAS No. : 122384-88-7

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规格 价格 是否有货 数量
500 μg ￥2400
In-stock
1 mg ￥3850
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of Amylin, amide, human:

Amylin, amide, human 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent[1].

体外研究
(In Vitro)

MCF-7 cells endogenously express human amylin receptor CTR1 and CTR2. Stimulation of the receptor with Amylin, amide, human results in the production of cAMP. Amylin, amide, human (0.001 nM-1000 μM) results in an EC50 of 35.2±7.5 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Amylin, amide, human 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF-7 cells
Concentration: 0.001 nM, 0.01 nM, 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10μM, 100 μM, 1000 μM
Incubation Time:
Result: Resulted in the production of cAMP with an EC50 of 35.2±7.5 nM.
体内研究
(In Vivo)

Amylin, amide, human (400 μg peptide /kg body weight) is injected by subcutaneous route in separated groups of swiss male mice. A typical PK curve for the free amylin is observed, with a half-time of 23 min[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss male mice (8 weeks old)[1]
Dosage: 400 μg peptide /kg body weight (Pharmacokinetic Analysis)
Administration: Subcutaneous route; 24 hours
Result: Half-time of 23 min.
分子量

3903.28

Formula

C165H261N51O55S2
CAS 号
性状

固体

颜色

White to off-white

Sequence

Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bridge: Cys2-Cys7)
Sequence Shortening

KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2 (Disulfide bridge: Cys2-Cys7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 4.76 mg/mL (1.22 mM; ultrasonic and adjust pH to 1 with CH3COOH)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2562 mL 1.2810 mL 2.5619 mL
5 mM --- --- ---
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 97.41%

COA (308 KB) RP-HPLC (111 KB) MS (205 KB)

产品使用指南 (1538 KB)
参考文献

Amylin, amide, human 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2562 mL 1.2810 mL 2.5619 mL 6.4049 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amylin, amide, human122384-88-7DAP amide, humanAmylin ReceptorAMYRGlucoregulatoryHormonepancreaticmetabolismglucosehomeostasisglucagonsecretiongastricemptyingsatietyInhibitorinhibitorinhibit

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