2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Betaine chloride

Betaine chloride  (Synonyms: 盐酸甜菜碱)

目录号: HY-N0739 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Betaine hydrochloride 是许多食物中发现的天然化合物，也是一种可维持正常 DNA 甲基化模式的活性甲基供体。

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Betaine chloride Chemical Structure

Betaine chloride Chemical Structure

CAS No. : 590-46-5

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Customer Review

Other Forms of Betaine chloride:

Betaine chloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns.

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

It is found that proliferation of HeLa cells is inhibited significantly upon exposure to increasing Betaine hydrochloride levels with the MTT test (p<0.05). The percentage of S phase cells in the low dose groups (<5 mg/mL) are distinctly higher than in high dose groups, and the rates of Sub-G1 phase are the opposite (p<0.05). A high concentration of Betaine hydrochloride (>5.0 mg/mL) significantly promotes the apoptosis of HeLa cells (p<0.01). SOD activities of the low dose groups are slightly higher than the control group (p<0.05), and there are obvious synchronicity and correlation among the expression of promoting apoptosis genes Bax, P53, Caspase 3 and apoptosis suppression gene Bcl-2. In response to an apoptosis-inducing stimulus, p53 and cyclin D1 can be activated with blockage of the cell cycle at G1/S or S/G2 checkpoints[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Betaine chloride 相关抗体:
体内研究
(In Vivo)

Liver-to-body weight ratio is attenuated by Betaine hydrochloride supplementation. When Betaine hydrochloride is added to the alcohol-containing liquid diet, both hepatic triglyceride (TG) accumulation and liver injury are significantly reduced. Betaine hydrochloride supplementation attenuates epididymal fat pad mass loss induced by chronic alcohol feeding. Betaine hydrochloride supplementation prevents the depletion of S-adenosylhomocysteine (SAM) and reduces the increase in S-adenosylhomocysteine (SAH), thereby improving the methylation state of the adipose tissue[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

153.61

Formula

C5H12ClNO2
CAS 号
性状

固体

颜色

White to off-white

中文名称

盐酸甜菜碱；甜菜碱盐酸盐
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (651.00 mM; 超声助溶)

DMSO 中的溶解度 : 5 mg/mL (32.55 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.5100 mL 32.5500 mL 65.0999 mL
5 mM 1.3020 mL 6.5100 mL 13.0200 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥98.0%

COA (285 KB) HNMR (173 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

Cytotoxic effects of Betaine hydrochloride are evaluated by MTT assays. Briefly, 5×103 HeLa or MCF-10A cells/well are seeded in a 96-well plate and cultured overnight. Then, different concentrations of Betaine hydrochloride (from 0 to 100 mg/mL) are added to each well, and the MTT assay is performed at 24, 48, 72 and 96 h after incubation. Cu/Zn-SOD activities are detected using the superoxide dismutase Assay Kit according to the manufacturer’s instructions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

Male C57BL/6 mice weighing 25±0.5 g are used in this study. Animals are randomly assigned to four groups (n=6 to 8 per group) and pair-fed a modified Lieber-DeCarli alcohol (AF) or isocaloric maltose dextrin control liquid diet (PF) for 5 weeks with a stepwise feeding procedure. The ethanol content starts at 30% of total calories and gradually increases up to 36% in the last week. Betaine hydrochloride is administered as a supplement in the liquid diets (both PF and AF) at a concentration of 0.5% (w/v), simultaneously with the alcohol. All animals have access to diet and water ad libitum. At the end of the experiment, the mice are killed after being deprived of food for 4 h, and the plasma, liver and epididymal fat pad samples are harvested for assays[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Betaine chloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 6.5100 mL 32.5500 mL 65.0999 mL 162.7498 mL
5 mM 1.3020 mL 6.5100 mL 13.0200 mL 32.5500 mL
10 mM 0.6510 mL 3.2550 mL 6.5100 mL 16.2750 mL
15 mM 0.4340 mL 2.1700 mL 4.3400 mL 10.8500 mL
20 mM 0.3255 mL 1.6275 mL 3.2550 mL 8.1375 mL
25 mM 0.2604 mL 1.3020 mL 2.6040 mL 6.5100 mL
30 mM 0.2170 mL 1.0850 mL 2.1700 mL 5.4250 mL
H2O 40 mM 0.1627 mL 0.8137 mL 1.6275 mL 4.0687 mL
50 mM 0.1302 mL 0.6510 mL 1.3020 mL 3.2550 mL
60 mM 0.1085 mL 0.5425 mL 1.0850 mL 2.7125 mL
80 mM 0.0814 mL 0.4069 mL 0.8137 mL 2.0344 mL
100 mM 0.0651 mL 0.3255 mL 0.6510 mL 1.6275 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Betaine590-46-5盐酸甜菜碱甜菜碱盐酸盐Endogenous MetaboliteInhibitorinhibitorinhibit

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