2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Biperiden

Biperiden  (Synonyms: 比哌立登; 碧卜利旦; KL 373)

目录号: HY-13204A 纯度: 99.74%
COA 产品使用指南

摩尔计算器

Biperiden (KL 373) 是一种非选择性毒蕈碱受体 (muscarinic receptor) 拮抗剂，可以与 M1 毒蕈碱受体竞争性结合，从而抑制乙酰胆碱 (acetylcholine) 并增强中枢神经系统中多巴胺信号传导。 Biperiden 可用于帕金森病以及其他相关精神疾病的研究。

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Biperiden Chemical Structure

Biperiden Chemical Structure

CAS No. : 514-65-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1100
In-stock
5 mg ￥1000
In-stock
10 mg ￥1600
In-stock
25 mg ￥3200
In-stock
50 mg ￥5120
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Other Forms of Biperiden:

Biperiden 相关抗体

Top Publications Citing Use of Products

查看 mAChR 亚型特异性产品:

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders[1][2].

体外研究
(In Vitro)

Biperiden (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Biperiden 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Panc-1, Panc-2 and BxPC3 human pancreatic ductal adenocarcinoma cells
Concentration: 29.6 μg/mL
Incubation Time: 72 hours
Result: Inhibited cell proliferation at 72 hours significantly by reducing nuclear c-Rel translocation.
体内研究
(In Vivo)

Biperiden (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1].
Biperiden (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; everyday; 3 weeks
Result: Tumor size reduced by 83%.
Animal Model: Male Wistar rats (200-250 g)[2]
Dosage: 8 mg/kg
Administration: Intraperitoneal injection; every 8 hours; 10 days
Result: Reduced late seizures by about three times with no affecting emotional memory damage.
Clinical Trial
分子量

311.46

Formula

C21H29NO
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (160.53 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : 1.82 mg/mL (5.84 mM; ultrasonic and warming and adjust pH to 5 with HCl and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.2107 mL 16.0534 mL 32.1069 mL
5 mM 0.6421 mL 3.2107 mL 6.4214 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Biperiden 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.2107 mL 16.0534 mL 32.1069 mL 80.2671 mL
5 mM 0.6421 mL 3.2107 mL 6.4214 mL 16.0534 mL
DMSO 10 mM 0.3211 mL 1.6053 mL 3.2107 mL 8.0267 mL
15 mM 0.2140 mL 1.0702 mL 2.1405 mL 5.3511 mL
20 mM 0.1605 mL 0.8027 mL 1.6053 mL 4.0134 mL
25 mM 0.1284 mL 0.6421 mL 1.2843 mL 3.2107 mL
30 mM 0.1070 mL 0.5351 mL 1.0702 mL 2.6756 mL
40 mM 0.0803 mL 0.4013 mL 0.8027 mL 2.0067 mL
50 mM 0.0642 mL 0.3211 mL 0.6421 mL 1.6053 mL
60 mM 0.0535 mL 0.2676 mL 0.5351 mL 1.3378 mL
80 mM 0.0401 mL 0.2007 mL 0.4013 mL 1.0033 mL
100 mM 0.0321 mL 0.1605 mL 0.3211 mL 0.8027 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biperiden514-65-8KL 373KL373KL-373mAChRMuscarinic acetylcholine receptorMuscarinic receptor antagonistParkinson's diseaseAnticholinergicInhibitorinhibitorinhibit

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