2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Carbacyclin

Carbacyclin  (Synonyms: Carbaprostacyclin; Carba-PGI2)

目录号: HY-112322 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Carbacyclin 是 PGI2 的类似物，为前列腺环素 (prostacyclin (PGI2)) 受体激动剂和血管舒张剂，能够有效抑制血小板聚集；Carbacyclin 同时可以通过 PPARδ 来诱导 CPT-1 mRNA 的表达，不依赖 IP 受体信号通路。

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Carbacyclin Chemical Structure

Carbacyclin Chemical Structure

CAS No. : 69552-46-1

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规格 价格 是否有货 数量
100 μg (2.85 mM * 100 μL in Methyl acetate) ￥2250
In-stock
500 μg (2.85 mM * 500 μL in Methyl acetate) ￥3900
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Customer Review

Carbacyclin 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation.

IC50 & Target

PGI2 Receptor

 

体外研究
(In Vitro)

Carbacyclin is an agonist of prostacyclin (PGI2) receptor[1]. Carbacyclin acts as an inhibitor of platelet aggregation induced by ADP or collagen in vitro[2]. Carbacyclin is a PGI2 analogue, activates CPT-1 mRNA expression through PPARδ, independent of the IP receptor signaling pathway. Carbacyclin (0.02 μM to 20 μM) activates the IP receptor signaling pathway via PKA, and such an effect is inhibited by H-89, a PKA inhibitor. Carbacyclin (0.02-80 μM) increases PPRE promoter activity via PPARδ independent of the IP receptor signaling pathway in cardiomyocytes[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Carbacyclin 相关抗体:
体内研究
(In Vivo)

Carbacyclin is 0.03 times as active as prostacyclin on inhibiting platelet aggregation in human, dog or rabbit plasma[2]. Carbacyclin (100 μg, i.p.) induces CPT-1 mRNA expression in murine heart[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

350.49

Formula

C21H34O4
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

卡巴环素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 5 mg/mL (14.27 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (282 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[3]

Primary cultures of neonatal rat cardiomyocytes are prepared from the ventricles of 1-day-old Wistar rats, and are seeded at a density of 4 × 105/6-well plastic plates, 9 × 105/60 mm dishes, or 3 × 106/100 mm dishes with Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal calf serum (FCS). After 40 h of incubation, cultured cardiomyocytes are serum-starved for 8 h before Carbacyclin stimulation.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[3]

Mice[3]
Ten to twelve week-old male C57BL/6 mice (20-25 g) are used in the experiment. Mice (n = 4) are injected intraperitoneally with 100 μg of Carbacyclin, and are sacrificed at the times indicated. The hearts are excised, and the ventricles are then homogenized with 3 mL of Isogen for the following total RNA extraction procedure[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Carbacyclin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8531 mL 14.2657 mL 28.5315 mL 71.3287 mL
5 mM 0.5706 mL 2.8531 mL 5.7063 mL 14.2657 mL
10 mM 0.2853 mL 1.4266 mL 2.8531 mL 7.1329 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carbacyclin69552-46-1Carbaprostacyclin Carba-PGI2卡巴环素Prostaglandin ReceptorInhibitorinhibitorinhibit

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目录号：
HY-112322
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