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Carnostatine  (Synonyms: SAN9812)

目录号: HY-112431
产品使用指南

摩尔计算器

Carnostatine (SAN9812) 是一种有效的选择性肌肽酶 1 (CN1) 抑制剂，对人重组 CN1 的 Ki 值为 11 nM。Carnostatine 有潜力用于糖尿病性肾病 (DN) 的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Carnostatine hydrochloride 通常具有更好的水溶性和稳定性。

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Carnostatine Chemical Structure

Carnostatine Chemical Structure

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Carnostatine 的其他形式现货产品:

Customer Review

Other Forms of Carnostatine:

Carnostatine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Carnostatine (SAN9812) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1. Carnostatine (SAN9812) can be used for the treatment of diabetic nephropathy (DN)[1].

IC50 & Target

Ki: 11 nM (human CN1)[1]
体外研究
(In Vitro)

Carnostatine (SAN9812) also inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. Carnostatine, with an IC50 value of 18 nM on human recombinant CN1 at a carnosine concentration of 200 µM, i.e., close to the Km of 190 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Carnostatine 相关抗体:
体内研究
(In Vivo)

Subcutaneous administration of 30 mg/kg Carnostatine (SAN9812) leads to a sustained reduction in circulating CN1 activity in human CN1 transgenic (TG) mice. Simultaneous administration of Carnosine and Carnostatine increases carnosine levels in plasma and kidney by up to 100-fold compared to treatment-naïve CN1-overexpressing mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human carnosinase (CNDP1) transgenic mice on a BTBR wt/ob background[1]
Dosage: 3 mg/kg i.v. or 30 mg/kg s.c. (Pharmacokinetic Analysis)
Administration: Single bolus administration
Result: Subcutaneous administration of 30 mg/kg led to a sustained reduction in circulating CN1 activity.
分子量

256.26

Formula

C10H16N4O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Carnostatine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CarnostatineSAN9812SAN 9812SAN-9812OthersCarnosinaseCN1Diabeticnephropathiesdiabetes ,T2DrenaldiseaseESRDInhibitorinhibitorinhibit

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