2. NF-κB
  3. NF-κB
  4. DHMEQ racemate

DHMEQ racemate  (Synonyms: rel-DHMEQ)

目录号: HY-14645B
产品使用指南

摩尔计算器

DHMEQ racemate 是一种 NF-κB 抑制剂。 DHMEQ racemate 抑制 NF-κB 的活性低于 (-)-DHMEQ。

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DHMEQ racemate Chemical Structure

DHMEQ racemate Chemical Structure

CAS No. : 287194-38-1

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规格 是否有货
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Customer Review

Other Forms of DHMEQ racemate:

DHMEQ racemate 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DHMEQ racemate is a NF-κB inhibitor. DHMEQ racemate is less active than (-)-DHMEQ.

IC50 & Target[1]

NF-κB

 

体外研究
(In Vitro)

DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibits TNF-a-induced NF-kB activation. (-)-DHMEQ is more potent and less toxic than DHMEQ racemate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DHMEQ racemate 相关抗体:
体内研究
(In Vivo)

The antiarthritic effects of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) are examined on type-II collagen-induced arthritis in DBA1/J mice. This animal model is widely used for evaluation of antirheumatic drugs because of its pathological similarities to human rheumatoid arthritis. The arthritis is elicited and scored. (-)-DHMEQ markedly inhibits type-II-collagen-induced arthritis in mice, whereas DHMEQ racemate tends to only slightly inhibit it[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

522.47

Formula

C13H11NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 32 mg/mL (61.25 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9140 mL 9.5699 mL 19.1399 mL
5 mM 0.3828 mL 1.9140 mL 3.8280 mL
查看完整储备液配制表

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

DHMEQ racemate 相关分类

完整储备液配制表

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9140 mL 9.5699 mL 19.1399 mL 47.8496 mL
5 mM 0.3828 mL 1.9140 mL 3.8280 mL 9.5699 mL
10 mM 0.1914 mL 0.9570 mL 1.9140 mL 4.7850 mL
15 mM 0.1276 mL 0.6380 mL 1.2760 mL 3.1900 mL
20 mM 0.0957 mL 0.4785 mL 0.9570 mL 2.3925 mL
25 mM 0.0766 mL 0.3828 mL 0.7656 mL 1.9140 mL
30 mM 0.0638 mL 0.3190 mL 0.6380 mL 1.5950 mL
40 mM 0.0478 mL 0.2392 mL 0.4785 mL 1.1962 mL
50 mM 0.0383 mL 0.1914 mL 0.3828 mL 0.9570 mL
60 mM 0.0319 mL 0.1595 mL 0.3190 mL 0.7975 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHMEQ287194-38-1rel-DHMEQNF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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目录号：
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