2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. Encequidar hydrochloride

Encequidar hydrochloride  (Synonyms: HM30181 hydrochloride; HM30181A hydrochloride)

目录号: HY-13646B
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摩尔计算器

Encequidar hydrochloride (HM30181 hydrochloride)是一种口服P-glycoprotein (P-gp)抑制剂，具有增强P-gp底物药物的口服生物利用度活性。Encequidar在多种MDR1抑制剂中显示出最高的效力，IC50=0.63nM。Encequidar有效阻止了在MDCK单层细胞中的紫杉醇的跨上皮运输，IC50=35.4nM。

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Encequidar hydrochloride Chemical Structure

Encequidar hydrochloride Chemical Structure

CAS No. : 849675-88-3

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Encequidar hydrochloride 的其他形式现货产品:

Other Forms of Encequidar hydrochloride:

Encequidar hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Encequidar hydrochloride (HM30181 hydrochloride) is an oral P-glycoprotein (P-gp) inhibitor with the activity of enhancing the oral bioavailability of P-gp substrate drugs. Encequidar shows the highest potency among various MDR1 inhibitors, with IC50=0.63nM. Encequidar effectively blocks the transepithelial transport of paclitaxel in MDCK monolayer cells, with IC50=35.4nM[1].

分子量

725.19

Formula

C38H37ClN6O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Encequidar hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Encequidar849675-88-3HM30181HM30181AHM 30181HM-30181P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Inhibitorinhibitorinhibit

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