1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. GDC-0927 Racemate

GDC-0927 Racemate  (Synonyms: SRN-927 Racemate)

目录号: HY-111484A
Data Sheet 产品使用指南

GDC-0927 Racemate (SRN-927 Racemate) 是雌激素受体 (estrogen receptor) 的降解剂,能够有效抑制 ER-α 的活性,IC50 值为 0.2 nM,可用于雌激素受体有关的疾病。

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GDC-0927 Racemate Chemical Structure

GDC-0927 Racemate Chemical Structure

CAS No. : 1443983-36-5

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Other Forms of GDC-0927 Racemate:

查看 Estrogen Receptor/ERR 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GDC-0927 Racemate (SRN-927 Racemate) is an estrogen receptor (ER) degrader that can effectively inhibit the activity of ER-α with an IC50 value of 0.2 nM and can be used in diseases related to estrogen receptors.

IC50 & Target

IC50: 0.2 nM (ER-α)[1]

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
0.2 nM
Compound: 17h
Antiproliferative activity against human MCF7 cells after 5 days by CellTiter-Glo assay
Antiproliferative activity against human MCF7 cells after 5 days by CellTiter-Glo assay
[PMID: 30655946]
MCF7 IC50
0.3 nM
Compound: 17h
Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assay
Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assay
[PMID: 30655946]
体外研究
(In Vitro)

GDC-0927 Racemate (Example 1) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. GDC-0927 Racemate reduces the viability of MCF7 cells with an IC50 of 0.21 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

461.52

Formula

C28H28FNO4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
GDC-0927 Racemate
目录号:
HY-111484A
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