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Pareptide monohydrochloride  (Synonyms: 帕立太特盐酸盐)

目录号: HY-U00271
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摩尔计算器

Pareptide monohydrochloride 是一种促黑素抑制因子 (MIF) 的类似物。

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Pareptide monohydrochloride Chemical Structure

Pareptide monohydrochloride Chemical Structure

CAS No. : 63236-23-7

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Pareptide monohydrochloride 相关抗体

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  • 生物活性

  • 实验参考方法

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  • 参考文献

生物活性

Pareptide monohydrochloride is a melanotropin-inhibiting factor (MIF) metabolically stable analogue.

体内研究
(In Vivo)

Chronic coadministration of Pareptide (0.25 mg/kg, SC, BID, 3.5 days) to mice pretreated with Haloperidol (8.0 mg/kg, IP, BID, 3 days) significantly increases the cataleptic effects of a smaller challenge dose of Haloperidol (2.0 mg/kg, IP) given 15 hours after the last pretreatment injections (p<0.01)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

334.84

Formula

C14H27ClN4O3
CAS 号
中文名称

帕立太特盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Mice[1]
Male albino mice of a Swiss-Webster derived strain and eighing from 26-34 g are used. Single doses of MIF-I (0.03-2.0 mg/kg, SC) and chronic pretreatments with MIF-I (0,03-2.0 mg/kg, SC, BID, 3.5 days) or Pareptide (0.25 mg/kg, SC, BID, 3.5 days) do not affect the acute cataleptic response to Haloperidol in the mouse. Pareptide is given SC in a 5 mL/kg injection volume. Chronic pretreatment with Haloperidol (8.0 mg/kg, IP, BID, 3 days) decreases the duration of catalepsy in mice given smaller challenge doses of Haloperidol (2.0 or 3.0 mg/kg, IP) 15 hours after the last pretreatment injections. Administration of either MIF-I or Pareptide to mice also chronically pretreated with Haloperidol antagonizes the development of tolerance[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Pareptide monohydrochloride 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Pareptide monohydrochloride63236-23-7帕立太特盐酸盐OthersInhibitorinhibitorinhibit

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