2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Irindalone

Irindalone  (Synonyms: Lu 21-​098)

目录号: HY-101632
产品使用指南

摩尔计算器

Irindalone 是一种 5-羟色胺 (5-HT2) 拮抗剂。

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Irindalone Chemical Structure

Irindalone Chemical Structure

CAS No. : 96478-43-2

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Irindalone 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Irindalone is a novel serotonin 5-HT2 antagonist.

IC50 & Target

5-HT2 Receptor

 

体外研究
(In Vitro)

Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT2 receptors and about a 10 times lower affinity for α1-adrenoceptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Irindalone 相关抗体:
体内研究
(In Vivo)

Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

408.51

Formula

C24H29FN4O
CAS 号
中文名称

茚达酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Irindalone 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Irindalone96478-43-2Lu 21-​098茚达酮5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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